Monozygotic twins are discordant for chronic periodontitis: clinical and bacteriological findings

Journal of Clinical Periodontology
Gaudy L Torres de HeensUbele van der Velden

Abstract

The aim of this study was to assess, in monozygotic (MZ) and dizygotic (DZ) twin pairs in whom the proband of the twin pair was suffering from moderate to severe chronic periodontitis, the contribution of genetics, periodontal pathogens and lifestyle factors towards the clinical phenotype. For this study, 18 adult twin pairs were selected on the basis of interproximal attachment loss (AL) >or=5 mm in >or=2 non-adjacent teeth in one twin member. The study included 10 MZ and eight DZ twin pairs, in whom the periodontal condition, presence of periodontal pathogens, educational level, smoking behaviour and body mass index (BMI) were evaluated. Both MZ and DZ twins were discordant regarding AL and alveolar bone loss. Discordance was greater in DZ compared with MZ twins. In MZ twins, the discordance could not be explained by education, smoking, BMI and periodontal pathogens. In DZ twins, 45.6% of the discordance could be explained by more pack-years of the probands. The results confirm a possible role of genetic factors in periodontitis. However, the magnitude of the genetic effects on disease severity may have been overestimated previously.

References

Nov 11, 1991·Journal of Dental Research·B S MichalowiczB L Pihlstrom
May 1, 1991·Journal of Periodontology·B S MichalowiczB L Pihlstrom
Jan 1, 1969·Journal of Periodontal Research·S G CiancioJ J Cunat
Dec 1, 1993·Journal of Periodontology·L A CoreyH A Schenkein
Mar 1, 1994·Journal of Periodontology·S G GrossiR J Genco
Oct 1, 1993·British Journal of Rheumatology·A J SilmanW E Ollier
Feb 1, 1997·Genetics·C H Brenner
May 4, 1999·Journal of Periodontology·B S MichalowiczB L Pihlstrom
Feb 22, 2000·Annals of the New York Academy of Sciences·T F DruryM Adesanya
Dec 29, 2000·Journal of Periodontology·B S MichalowiczH A Schenkein
Feb 28, 2001·Trends in Genetics : TIG·A Petronis
Jul 10, 2002·Periodontology 2000·Jasim M Albandar, Thomas E Rams
Jun 23, 2005·Behavior Genetics·Jacqueline M VinkDorret I Boomsma
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FragaManel Esteller
Sep 1, 2005·Journal of Clinical Periodontology·Bruno G LoosMarja L Laine
Sep 1, 2005·Journal of Clinical Periodontology·Richard M PalmerDavid A Scott
Dec 13, 2005·Journal of Affective Disorders·Christel M MiddeldorpDorret I Boomsma
Jul 6, 2006·Journal of Clinical Periodontology·Badiah BaharinRon F Wilson
Jan 30, 2007·Journal of Clinical Periodontology·Farnaz TabriziBjörn Klinge
Aug 19, 2007·Journal of Periodontology·Roy C Page, Paul I Eke
Aug 19, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Allan Vaag, Pernille Poulsen
Jan 15, 2008·Addiction·Marcus R Munafò, Elaine C Johnstone
Feb 26, 2008·Journal of Clinical Periodontology·Pekka YlöstaloMatti Knuuttila
Mar 18, 2008·Biological Psychology·Anouk den BraberDorret I Boomsma
May 27, 2008·Journal of the American Dietetic Association·Gail P A Kauwell
May 1, 2000·Journal of Periodontology·Scott L Tomar, Samira Asma
Jul 1, 2007·Journal of Periodontology·Roy C Page, Paul I Eke

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Citations

Sep 18, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Thomas BuchheitAndrew Shaw
Nov 26, 2010·Dental Clinics of North America·Dana L Wolf, Ira B Lamster
Feb 26, 2011·Journal of Clinical Periodontology·U Van der VeldenI L C Chapple
Oct 11, 2012·International Journal of Dental Hygiene·S J Fokkema
Apr 12, 2013·Periodontology 2000·Robert J Genco, Wenche S Borgnakke
Jul 27, 2010·Journal of Clinical Periodontology·Gaudy L Torres de HeensUbele van der Velden
Jun 5, 2015·Systems Biology in Reproductive Medicine·Saynur YilmazNafiye Yilmaz
Apr 28, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sezcan MumusogluGurkan Bozdag
Apr 12, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Daigo IkegamiMinoru Narita
Dec 18, 2020·Journal of Clinical Medicine·Małgorzata KozakAndrzej Pawlik

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