Monozygotic twins are discordant for chronic periodontitis: white blood cell counts and cytokine production after ex vivo stimulation

Journal of Clinical Periodontology
Gaudy L Torres de HeensUbele van der Velden

Abstract

The aim of this study was to investigate the extent of concordance in the number of leucocytes and their cytokine secretion after ex vivo stimulation in a twin population discordant for the amount of periodontal breakdown. Venous blood was collected from 18 adult twin pairs (10 monozygotic and eight dizygotic twins). Each twin pair consisted of a diseased twin (proband) and his/her co-twin. In venous blood, leucocytes were counted. The cytokines interleukin (IL)-1beta, IL-6, IL-8, IL-10 and IL-12p40 were assessed after stimulation of monocytic cells, while IL-13 and interferon (IFN)-gamma were determined after lymphocytic stimulation. In the study population as a whole, probands showed higher total numbers of leucocytes and lower IL-12p40 levels compared with their co-twins. In monozygotic twins, no difference was found in the leucocyte counts, but probands secreted more IL-6 than their co-twins; an opposite trend was found for IL-12p40. The results suggest that the observed discordance in periodontal breakdown in the studied monozygotic twin population may be related to the relatively high levels of IL-6 and the low levels of IL-12p40 secretion after ex vivo stimulation of whole-blood cell cultures. This cytokine secretion pro...Continue Reading

References

May 1, 1991·Journal of Periodontology·B S MichalowiczB L Pihlstrom
Oct 1, 1994·Immunobiology·E Skamene
Feb 1, 1995·The Journal of Experimental Medicine·T C van der Pouw KraanL A Aarden
Sep 1, 1994·Journal of Periodontology·S S ManhartT M Petro
Dec 1, 1993·Journal of Periodontology·L A CoreyH A Schenkein
Jun 1, 1993·Scottish Medical Journal·M KweiderD A McGowan
Jan 1, 1993·Annual Review of Immunology·K W MooreT R Mosmann
Jan 1, 1997·Journal of Clinical Periodontology·K S KornmanG W Duff
Dec 17, 1997·Nature Genetics·N MartinG Machin
Jun 1, 1994·Periodontology 2000·J L Ebersole, M A Taubman
Jan 15, 1999·Human Molecular Genetics·D J GraingerT D Spector
Apr 25, 2000·Annual Review of Medicine·W B Ershler, E T Keller
Dec 29, 2000·Journal of Periodontology·B S MichalowiczH A Schenkein
Aug 15, 2001·Acta Odontologica Scandinavica·D F Kinane, D F Lappin
Aug 15, 2001·Acta Odontologica Scandinavica·G J Seymour, E Gemmell
Mar 6, 2002·Clinical and Experimental Immunology·S J FokkemaU van der Velden
Apr 10, 2002·Journal of Clinical Periodontology·Claudia ChristanJean-Pierre Bernimoulin
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·E GemmellG J Seymour
Apr 27, 2004·Periodontology 2000·Erica Gemmell, Gregory J Seymour
Jan 12, 2007·Periodontology 2000·Erica GemmellGregory J Seymour
Jul 27, 2007·Retrovirology·Juan Lama, Vicente Planelles
Mar 18, 2008·Biological Psychology·Anouk den BraberDorret I Boomsma
Nov 1, 2008·Journal of Periodontal Research·G L Torres de HeensB G Loos
Jan 20, 2009·Nature Reviews. Immunology·Christopher B WilsonMasayuki Sekimata
Jun 6, 2009·Journal of Dental Research·S P Barros, S Offenbacher
Jul 27, 2010·Journal of Clinical Periodontology·Gaudy L Torres de HeensUbele van der Velden

❮ Previous
Next ❯

Citations

Jan 23, 2016·Clinical Oral Implants Research·Trang N Nguyen VoShohei Kasugai
Dec 11, 2013·Periodontology 2000·Annsofi JohannsenAnders Gustafsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.