Monte Carlo algorithm for efficient simulation of time-resolved fluorescence in layered turbid media

Optics Express
A LiebertRainer Macdonald

Abstract

We present an efficient Monte Carlo algorithm for simulation of time-resolved fluorescence in a layered turbid medium. It is based on the propagation of excitation and fluorescence photon bundles and the assumption of equal reduced scattering coefficients at the excitation and emission wavelengths. In addition to distributions of times of arrival of fluorescence photons at the detector, 3-D spatial generation probabilities were calculated. The algorithm was validated by comparison with the analytical solution of the diffusion equation for time-resolved fluorescence from a homogeneous semi-infinite turbid medium. It was applied to a two-layered model mimicking intra- and extracerebral compartments of the adult human head.

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Citations

Sep 4, 2009·Journal of Biomedical Optics·Anthony A TanbakuchiArthur F Gmitro
Aug 20, 2010·Optics Express·Katarzyna ZarychtaJean-Michel Tualle
Oct 14, 2010·Optics Express·ChingSeong TanHin Yong Wong
Oct 4, 2012·Physics in Medicine and Biology·Daniel MilejAdam Liebert
Oct 17, 2014·Optics Express·Sven LeyrePeter Hanselaer
Jan 24, 2013·Physics in Medicine and Biology·S WojtkiewiczR Maniewski
Oct 6, 2012·Optics Express·Sven LeyrePeter Hanselaer
Mar 15, 2016·Applied Optics·Daniel MilejKeith St Lawrence
Jan 19, 2012·Biomedical Optics Express·F MartelliP Di Ninni
Mar 4, 2014·Physics in Medicine and Biology·Daniel MilejAdam Liebert
Nov 30, 2016·Biomedical Optics Express·Daniel MilejKeith St Lawrence
Apr 5, 2012·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Ludovic G CoppelPer Edström
Apr 30, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mario ForcioneAntonio Belli
Dec 4, 2012·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Angelo Sassaroli, Fabrizio Martelli
Dec 27, 2016·Biomedical Optics Express·P SawoszA Liebert

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