Monte Carlo based determination of dose distribution for some patch sources employed for radionuclide skin therapy

Australasian Physical & Engineering Sciences in Medicine
Azam AfzalifarHamid Reza Baghani

Abstract

Several methods are introduced for skin cancer treatment. An encouraging method is radionuclide skin therapy, where high-energy beta emitting radionuclides such as 32P, 90Y, 188Re and 166Ho are employed for skin irradiation. This study aimed to calculate the dose distribution for mentioned radionuclides at different layers of skin phantom through Monte Carlo simulation. Depth dose distribution, transverse dose profile and isodose curves related to the patch sources under investigation were calculated by MCNPX code. All of calculations were performed inside a developed skin phantom. Obtained results were compared with those reported by other studies to evaluate the validity of simulations. The results showed that the 166Ho and 32P have steeper dose gradient within the depth which can lead to the better normal tissue sparing. Simulated depth dose distributions were in a good agreement with other published studies and confirmed the validity of performed simulations. The obtained transverse dose profiles at 0.2 mm depth had acceptable symmetry and flatness that can improve the dose uniformity within the target area. Calculated isodose curves showed that the 90% isodose level covers a circular area with the diameter of around 8 mm f...Continue Reading

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Citations

Apr 17, 2021·Computer Methods and Programs in Biomedicine·Sahar SheikholeslamiBagher Farhood

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Methods Mentioned

BETA
electron scattering

Software Mentioned

MCNPX

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