Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms

Applied Optics
Gregory M Palmer, Nirmala Ramanujam

Abstract

A flexible and fast Monte Carlo-based model of diffuse reflectance has been developed for the extraction of the absorption and scattering properties of turbid media, such as human tissues. This method is valid for a wide range of optical properties and is easily adaptable to existing probe geometries, provided a single phantom calibration measurement is made. A condensed Monte Carlo method was used to speed up the forward simulations. This model was validated by use of two sets of liquid-tissue phantoms containing Nigrosin or hemoglobin as absorbers and polystyrene spheres as scatterers. The phantoms had a wide range of absorption (0-20 cm(-1)) and reduced scattering coefficients (7-33 cm(-1)). Mie theory and a spectrophotometer were used to determine the absorption and reduced scattering coefficients of the phantoms. The diffuse reflectance spectra of the phantoms were measured over a wavelength range of 350-850 nm. It was found that optical properties could be extracted from the experimentally measured diffuse reflectance spectra with an average error of 3% or less for phantoms containing hemoglobin and 12% or less for phantoms containing Nigrosin.

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Citations

May 10, 2008·Journal of Biomedical Optics·Gregory M Palmer, Nirmala Ramanujam
Nov 22, 2008·Journal of Biomedical Optics·Narasimhan RajaramJames W Tunnell
Nov 22, 2008·Journal of Biomedical Optics·Arjen AmelinkHenricus J C M Sterenborg
Jan 7, 2009·Journal of Biomedical Optics·Erik AlerstamStefan Andersson-Engels
Jan 7, 2009·Journal of Biomedical Optics·Crystal Redden WeberRebecca Richards-Kortum
May 2, 2009·Journal of Biomedical Optics·Gregory M PalmerNirmala Ramanujam
Nov 9, 2010·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Nov 9, 2010·Journal of Biomedical Optics·Vivide Tuan-Chyan ChangNirmala Ramanujam
Feb 2, 2011·Journal of Biomedical Optics·Bing YuNirmala Ramanujam
Oct 28, 2011·Journal of Biomedical Optics·Zhenzhi ShiKexin Xu
May 9, 2012·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Nov 10, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gregory M PalmerMark W Dewhirst
Mar 10, 2009·Current Opinion in Biotechnology·J Quincy BrownNirmala Ramanujam
Nov 30, 2007·Computer Methods and Programs in Biomedicine·T BinzoniA H Gandjbakhche
Jun 20, 2007·Computer Methods and Programs in Biomedicine·K P B CracknellI Grierson
Sep 13, 2015·Mathematical Biosciences·Laura VinckenboschTiphaine Obara
Aug 19, 2007·IEEE Transactions on Bio-medical Engineering·Gregory M Palmer, Nirmala Ramanujam
May 9, 2009·IEEE Transactions on Bio-medical Engineering·Janelle E BenderNirmala Ramanujam
Aug 29, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Benjamin L VigliantiGregory M Palmer
May 5, 2016·International Journal of Computer Assisted Radiology and Surgery·Sebastian J WirkertLena Maier-Hein

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