Monte Carlo-based inverse model for calculating tissue optical properties. Part II: Application to breast cancer diagnosis

Applied Optics
Gregory M PalmerNirmala Ramanujam

Abstract

The Monte Carlo-based inverse model of diffuse reflectance described in part I of this pair of companion papers was applied to the diffuse reflectance spectra of a set of 17 malignant and 24 normal-benign ex vivo human breast tissue samples. This model allows extraction of physically meaningful tissue parameters, which include the concentration of absorbers and the size and density of scatterers present in tissue. It was assumed that intrinsic absorption could be attributed to oxygenated and deoxygenated hemoglobin and beta-carotene, that scattering could be modeled by spheres of a uniform size distribution, and that the refractive indices of the spheres and the surrounding medium are known. The tissue diffuse reflectance spectra were evaluated over a wavelength range of 400-600 nm. The extracted parameters that showed the statistically most significant differences between malignant and nonmalignant breast tissues were hemoglobin saturation and the mean reduced scattering coefficient. Malignant tissues showed decreased hemoglobin saturation and an increased mean reduced scattering coefficient compared with nonmalignant tissues. A support vector machine classification algorithm was then used to classify a sample as malignant or ...Continue Reading

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Citations

Jan 1, 2008·Journal of Biomedical Optics·Obrad R SćepanovićMichael S Feld
May 10, 2008·Journal of Biomedical Optics·Gregory M Palmer, Nirmala Ramanujam
May 10, 2008·Journal of Biomedical Optics·Zoya VolynskayaMichael S Feld
Nov 22, 2008·Journal of Biomedical Optics·Arjen AmelinkHenricus J C M Sterenborg
May 2, 2009·Journal of Biomedical Optics·Gregory M PalmerNirmala Ramanujam
Nov 9, 2010·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Feb 2, 2011·Journal of Biomedical Optics·Bing YuNirmala Ramanujam
Aug 3, 2011·Journal of Biomedical Optics·Wenfeng XiaSrirang Manohar
Oct 21, 2006·Journal of Mammary Gland Biology and Neoplasia·John M BooneThomas R Nelson
Jul 25, 2012·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Wei-Liang ChenChen-Yuan Dong
Nov 10, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gregory M PalmerMark W Dewhirst
Mar 10, 2009·Current Opinion in Biotechnology·J Quincy BrownNirmala Ramanujam
Jun 20, 2007·Computer Methods and Programs in Biomedicine·K P B CracknellI Grierson
Oct 6, 2009·American Journal of Surgery·Lee G WilkeNimmi Ramanujam
May 9, 2009·IEEE Transactions on Bio-medical Engineering·Janelle E BenderNirmala Ramanujam
Mar 1, 2012·Radiation Research·Gregory M PalmerMark W Dewhirst
Mar 9, 2011·Technology in Cancer Research & Treatment·R H Wilson, M-A Mycek
Nov 4, 2017·Physics in Medicine and Biology·Jennifer E PhippsLaura Marcu
Jun 22, 2016·Journal of Biomedical Optics·Stephanie KennedyJoseph Geradts
Dec 14, 2006·Lasers in Surgery and Medicine·Stacy R MillonNirmala Ramanujam
Sep 17, 2008·Optics Express·Changfang ZhuNirmala Ramanujam
Oct 9, 2019·Journal of Biophotonics·Akhil KallepalliMark A Richardson
Mar 14, 2014·Journal of Biomedical Optics·Haiyan XieStefan Andersson-Engels

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