Monte Carlo dosimetry for forthcoming clinical trials in x-ray microbeam radiation therapy

Physics in Medicine and Biology
I Martinez-RoviraYolanda Prezado

Abstract

The purpose of this work is to define safe irradiation protocols in microbeam radiation therapy. The intense synchrotron-generated x-ray beam used for the treatment is collimated and delivered in an array of 50 microm-sized rectangular fields with a centre-to-centre distance between microplanes of 400 microm. The absorbed doses received by the tumour and the healthy tissues in a human head phantom have been assessed by means of Monte Carlo simulations. The identification of safe dose limits is carried out by evaluating the maximum peak and valley doses achievable in the tumour while keeping the valley doses in the healthy tissues under tolerances. As the skull receives a significant fraction of the dose, the dose limits are referred to this tissue. Dose distributions with high spatial resolution are presented for various tumour positions, skull thicknesses and interbeam separations. Considering a unidirectional irradiation (field size of 2 x 2 cm(2)) and a centrally located tumour, the largest peak and valley doses achievable in the tumour are 55 Gy and 2.6 Gy, respectively. The corresponding maximum valley doses received by the skin, bone and healthy brain are 4 Gy, 14 Gy and 7 Gy (doses in one fraction), respectively, i.e. wi...Continue Reading

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Citations

Apr 20, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·I Martínez-RoviraY Prezado
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May 31, 2017·Medical Physics·Immaculada Martínez-RoviraYolanda Prezado
Jan 13, 2018·Physics in Medicine and Biology·Mattia DonzelliStefan Bartzsch
Oct 26, 2018·The British Journal of Radiology·Juergen MeyerYolanda Prezado
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Oct 2, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Alexandre OcadizJean-François Adam

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