Monte Carlo dosimetry for I125 and Pd103 eye plaque brachytherapy

Medical Physics
R M ThomsonD W O Rogers

Abstract

A Monte Carlo study of dosimetry for eye plaque brachytherapy is performed. BrachyDose, an EGSnrc user code which makes use of Yegin's multi-geometry package, is used to fully model I125 (model 6711) and Pd103 (model 200) brachytherapy seeds and the standardized plaques of the Collaborative Ocular Melanoma Study (COMS). Three-dimensional dose distributions in the eye region are obtained. In general, dose to water is scored; however, the implications of replacing water with eye tissues are explored. The effect of the gold alloy (Modulay) backing is investigated and the dose is found to be sensitive to the elemental composition of the backing. The presence of the silicone polymer (Silastic) seed carrier results in substantial dose decreases relative to water, particularly for Pd103. For a 20mm plaque with a Modulay backing and Silastic insert, fully loaded with 24 seeds, the dose decrease relative to water is of the order of 14% for I125 and 20% for Pd103 at a distance of 1cm from the inner sclera along the plaque's central axis. For the configurations of seeds used in COMS plaques, interseed attenuation is a small effect within the eye region. The introduction of an air interface results in a dose reduction in its vicinity which...Continue Reading

References

Nov 1, 1991·Archives of Ophthalmology·P T FingerT K Ho
Mar 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M A AstrahanZ Petrovich
May 1, 1988·Medical Physics·A G KepkaR W Kline
Jun 1, 1987·Archives of Ophthalmology·J EarleD M Robertson
Sep 1, 1986·Medical Physics·S T Chiu-TsaoS Packer
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·P T FingerJ L Bosworth
Jul 1, 1993·Medical Physics·J A Meli, K A Motakabbir
Mar 1, 1993·Medical Physics·S T Chiu-TsaoJ C Liu
Mar 1, 1996·Medical Physics·A de la ZerdaH S Tsao
Dec 3, 2002·International Journal of Radiation Oncology, Biology, Physics·Paul T FingerAndrzej Szechter
Jan 7, 2003·Medical Physics·B R B WaltersD W O Rogers
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Subir NagUNKNOWN American Brachytherapy Society
Jun 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Amanda L KrintzDavid S Followill
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Melvin A Astrahan
Oct 10, 2008·Medical Physics·R E P Taylor, D W O Rogers
Jul 1, 2008·Medical Physics·Christopher S Melhus, Mark J Rivard

❮ Previous
Next ❯

Citations

Apr 1, 2011·Australasian Physical & Engineering Sciences in Medicine·Pooneh SaidiClaudio Tenreiro
Aug 5, 2016·Medical Physics·Hali MorrisonRon S Sloboda
Dec 2, 2017·Physics in Medicine and Biology·Rowan M ThomsonD W O Rogers
Mar 15, 2018·Current Opinion in Ophthalmology·David Reichstein, Kayla Karan
May 1, 2018·Journal of Applied Clinical Medical Physics·Mozhgan Rezaei KanaviHamid Ahmadieh
Apr 11, 2012·Retina·Kelly L ClassicJose S Pulido
May 16, 2012·Journal of Applied Clinical Medical Physics·Hualin ZhangYujin Qi
Mar 3, 2011·Medical Physics·Mark J RivardRavinder Nath
Jul 21, 2009·Medical Physics·Mark J RivardLuc Beaulieu
May 12, 2016·Journal of Applied Clinical Medical Physics·Somayeh AsadiS Farhad Masoudi
Sep 5, 2014·Medical Physics·Prakash AryalMark J Rivard
Nov 3, 2016·Physics in Medicine and Biology·Marc J P ChamberlandRowan M Thomson
Dec 25, 2015·Journal of Applied Clinical Medical Physics·Somayeh AsadiAli S Meigooni
May 17, 2017·Australasian Physical & Engineering Sciences in Medicine·Hadi RezaeiHesameddin Mostaghimi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.