Monte Carlo Estimation of Absorbed Dose Distributions Obtained from Heterogeneous 106 Ru Eye Plaques

Ocular Oncology and Pathology
F J ZaragozaLorenzo Brualla

Abstract

The distribution of the emitter substance in 106Ru eye plaques is usually assumed to be homogeneous for treatment planning purposes. However, this distribution is never homogeneous, and it widely differs from plaque to plaque due to manufacturing factors. By Monte Carlo simulation of radiation transport, we study the absorbed dose distribution obtained from the specific CCA1364 and CCB1256 106Ru plaques, whose actual emitter distributions were measured. The idealized, homogeneous CCA and CCB plaques are also simulated. The largest discrepancy in depth dose distribution observed between the heterogeneous and the homogeneous plaques was 7.9 and 23.7% for the CCA and CCB plaques, respectively. In terms of isodose lines, the line referring to 100% of the reference dose penetrates 0.2 and 1.8 mm deeper in the case of heterogeneous CCA and CCB plaques, respectively, with respect to the homogeneous counterpart. The observed differences in absorbed dose distributions obtained from heterogeneous and homogeneous plaques are clinically irrelevant if the plaques are used with a lateral safety margin of at least 2 mm. However, these differences may be relevant if the plaques are used in eccentric positioning.

Citations

Jan 19, 2018·Ocular Oncology and Pathology·Marion Eichmann
Feb 6, 2018·Medical Physics·Marcelino Hermida-López, Lorenzo Brualla
Jul 13, 2021·Medical Physics·Héctor Miras Del RíoJosé Antonio Terrón León
Aug 17, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·A K BakshiC P Kaushik
Aug 2, 2019·Ocular Oncology and Pathology·Francisco J ZaragozaLorenzo Brualla

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