Monte Carlo modeling of light propagation in the human head for applications in sinus imaging

Journal of Biomedical Optics
Albert E CerussiBrian Wong

Abstract

Sinus blockages are a common reason for physician visits, affecting one out of seven people in the United States, and often require medical treatment. Diagnosis in the primary care setting is challenging because symptom criteria (via detailed clinical history) plus objective imaging [computed tomography (CT) or endoscopy] are recommended. Unfortunately, neither option is routinely available in primary care. We previously demonstrated that low-cost near-infrared (NIR) transillumination correlates with the bulk findings of sinus opacity measured by CT. We have upgraded the technology, but questions of source optimization, anatomical influence, and detection limits remain. In order to begin addressing these questions, we have modeled NIR light propagation inside a three-dimensional adult human head constructed via CT images using a mesh-based Monte Carlo algorithm (MMCLAB). In this application, the sinus itself, which when healthy is a void region (e.g., nonscattering), is the region of interest. We characterize the changes in detected intensity due to clear (i.e., healthy) versus blocked sinuses and the effect of illumination patterns. We ran simulations for two clinical cases and compared simulations with measurements. The simul...Continue Reading

References

Nov 21, 1997·Archives of Otolaryngology--head & Neck Surgery·T BhattacharyyaF J Wippold
Sep 7, 2000·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·H DehghaniD T Delpy
Jul 18, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·T J KennyS B Tanner
Sep 28, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Richard M RosenfeldDavid L Witsell
Dec 21, 2010·Biomedical Optics Express·Qianqian Fang

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Citations

Sep 9, 2021·Tissue Engineering and Regenerative Medicine·Haeyoung LeeChulho Oak

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