Monte Carlo simulation of radiation transport and dose deposition from locally released gold nanoparticles labeled with111 In,177 Lu or90 Y incorporated into tissue implantable depots

Physics in Medicine and Biology
Priscilla LaiRaymond M Reilly

Abstract

Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (IT) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult. Previously, we reported the design of a nanoparticle depot (NPD) that can be implanted using PSI techniques and which facilitates controlled release of AuNP. We report here the 3D dose distribution resulting from a NPD incorporating AuNP labeled with electron emitters (90Y,177Lu,111In) of different energies using Monte Carlo based voxel level dosimetry. The MCNP5 Monte Carlo radiation transport code was used to assess differences in dose distribution from simulated NPD and conventional brachytherapy sources, positioned in breast tissue simulating material. We further compare these dose distributions in mice bearing subcutaneous human breast cancer xenografts implanted wit...Continue Reading

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Citations

Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Anthony KuRaymond M Reilly
May 5, 2018·Advanced Healthcare Materials·Myriam Laprise-PelletierMarc-André Fortin
Dec 31, 2020·Materials·Francisco SilvaAntónio Paulo
Jul 9, 2021·Nuclear Medicine and Biology·Noami DaemsAn Aerts

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