Monte Carlo simulation on a gold nanoparticle irradiated by electron beams

Physics in Medicine and Biology
James C L ChowDavid A Jaffray

Abstract

This study investigated the secondary electron production from a gold nanoparticle (GNP) irradiated by monoenergetic electron beams using Monte Carlo (MC) simulation. Spherical GNPs with diameters of 2, 50 and 100 nm in water were irradiated by monoenergetic electron beams with energies equal to 50 keV, 250 keV, 1 MeV and 4 MeV. MC simulations were performed using the Geant4 toolkit to determine the energy of the secondary electrons emitted from the GNPs. The mean effective range and deflection angle of the secondary electrons were tracked. Energy depositions inside and outside the nanoparticles due to the secondary electrons were also calculated. For comparisons, simulations were repeated by replacing the GNPs with water. Our results show that the mean effective range of secondary electrons increased with an increase of the GNP size and electron beam energy. For the electron beam energy and GNP size used in this study, the mean effective range was 0.5-15 µm outside the nanoparticle, which is approximately within the dimension of a living cell. The mean deflection angles varied from 78 to 83 degrees as per our MC results. The proportion of energy deposition inside the GNP versus that outside increased with the GNP size. This is...Continue Reading

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Citations

Feb 19, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·C WälzleinM Durante
Jun 9, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Spiridon V SpirouGeorge Loudos
Oct 6, 2016·International Journal of Radiation Biology·Mehdi MousaviRasoul Iraji Rad
Jun 4, 2015·Nanoscale·Khashayar GhandiMark S Gordon
May 31, 2017·Radiation Research·Mohammad RezaeeDavid A Jaffray
May 17, 2017·Australasian Physical & Engineering Sciences in Medicine·Hadi RezaeiHesameddin Mostaghimi
Mar 4, 2014·Physics in Medicine and Biology·C WälzleinM Durante
Mar 6, 2013·Physics in Medicine and Biology·D W O Rogers
Aug 18, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Gilnaz OmyanFaraz Kalantari
Feb 12, 2021·Radiation Oncology·Somayeh Sadat MehrniaAzim Arbabi
Dec 3, 2020·International Journal of Nanomedicine·Yao ChenJingbo Wu
Mar 14, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Somayeh Sadat MehrniaAzim Arbabi
Aug 4, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·L MaigneH Payno

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