Monte Carlo simulation tool for online treatment monitoring in hadrontherapy with in-beam PET: A patient study

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
E FiorinaM G Bisogni

Abstract

Hadrontherapy is a method for treating cancer with very targeted dose distributions and enhanced radiobiological effects. To fully exploit these advantages, in vivo range monitoring systems are required. These devices measure, preferably during the treatment, the secondary radiation generated by the beam-tissue interactions. However, since correlation of the secondary radiation distribution with the dose is not straightforward, Monte Carlo (MC) simulations are very important for treatment quality assessment. The INSIDE project constructed an in-beam PET scanner to detect signals generated by the positron-emitting isotopes resulting from projectile-target fragmentation. In addition, a FLUKA-based simulation tool was developed to predict the corresponding reference PET images using a detailed scanner model. The INSIDE in-beam PET was used to monitor two consecutive proton treatment sessions on a patient at the Italian Center for Oncological Hadrontherapy (CNAO). The reconstructed PET images were updated every 10 s providing a near real-time quality assessment. By half-way through the treatment, the statistics of the measured PET images were already significant enough to be compared with the simulations with average differences in...Continue Reading

Citations

Oct 28, 2019·The British Journal of Radiology·Francesca AlbertiniAntony Lomax
Jun 7, 2018·Physics in Medicine and Biology·Francesco PennazioPiergiorgio Cerello
Nov 24, 2020·Physics in Medicine and Biology·Harald PaganettiAntony John Lomax
Oct 19, 2020·Zeitschrift für medizinische Physik·Giorgia MeschiniGuido Baroni

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