Monte Carlo Simulations of Heat Deposition During Photothermal Skin Cancer Therapy Using Nanoparticles

Biomolecules
J Charles G JeynesTim J Harries

Abstract

Photothermal therapy using nanoparticles is a promising new approach for the treatment of cancer. The principle is to utilise plasmonic nanoparticle light interaction for efficient heat conversion. However, there are many hurdles to overcome before it can be accepted in clinical practice. One issue is a current poor characterization of the thermal dose that is distributed over the tumour region and the surrounding normal tissue. Here, we use Monte Carlo simulations of photon radiative transfer through tissue and subsequent heat diffusion calculations, to model the spatial thermal dose in a skin cancer model. We validate our heat rise simulations against experimental data from the literature and estimate the concentration of nanorods in the tumor that are associated with the heat rise. We use the cumulative equivalent minutes at 43 °C (CEM43) metric to analyse the percentage cell kill across the tumour and the surrounding normal tissue. Overall, we show that computer simulations of photothermal therapy are an invaluable tool to fully characterize thermal dose within tumour and normal tissue.

References

Jun 1, 1984·International Journal of Radiation Oncology, Biology, Physics·S A Sapareto, W C Dewey
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
May 20, 2008·Seminars in Cutaneous Medicine and Surgery·Mollie A MacCormack
Aug 1, 1948·Journal of Applied Physiology·H H PENNES
Sep 16, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·A H M M AritsN W J Kelleners-Smeets
Feb 16, 2011·Nanotoxicology·Francesca Larese FilonGiovanni Maina
Nov 7, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Ronan M ValentineHarry Moseley
May 15, 2013·Physics in Medicine and Biology·Steven L Jacques
Jul 18, 2014·Nanoscale·D JaqueJ García Solé
Mar 1, 2005·Photodiagnosis and Photodynamic Therapy·Ana P CastanoMichael R Hamblin
May 1, 2015·Physics in Medicine and Biology·C L CampbellH Moseley
May 17, 2015·Regulatory Toxicology and Pharmacology : RTP·Francesca Larese FilonMatteo Crosera
Jul 1, 2017·Biomedical Optics Express·Vesna CuplovSébastien Jan
Oct 19, 2017·PloS One·David Harris-BirtillDaniel S Elson
Sep 14, 2018·Scientific Reports·Hyun June MoonKi Wan Bong

❮ Previous
Next ❯

Citations

Jun 17, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ean H OoiJason K K Cheong
Jun 26, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Nethanel FriedmanOfra Benny

❮ Previous
Next ❯

Software Mentioned

Geant4
MATLAB
kWaveDiffusion
ARCTORUS
GATE
TORUS
wave

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Joan Estelrich, Maria Antònia Busquets
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Jakub Mesicek, Kamil Kuca
© 2021 Meta ULC. All rights reserved