Monthly follow-ups of interferon-γ release assays among health-care workers in contact with patients with TB

Chest
Jong Sun ParkJae-Joon Yim

Abstract

Interferon-γ (IFN-γ) release assays (IGRAs), which can overcome several limitations of the tuberculin skin test in detecting latent TB infection, were introduced recently in routine clinical practice. However, IGRAs are highly dynamic tests, and the T-cell responses tend to fluctuate over time. We wanted to evaluate the conversion and reversion rates of monthly IGRAs over 1 year among health-care workers (HCWs) in contact with patients with TB in South Korea, a country with an intermediate TB burden. Forty-nine HCWs in contact with patients with active pulmonary TB were prospectively enrolled. Interviews on exposure to patients with active TB, a physical examination, and a QuantiFERON TB Gold In-Tube assay (QFT-GIT) were carried out monthly for 1 year. Among 48 participants, 25 (52%) showed inconsistent results in serial testing. When an increase from< 0.35 IU/mL to ≥ 0.70 IU/mL was applied as the definition of a conversion, inconsistent IGRA results were identified in 13 participants (27.0%). Consistency in QFT-GIT results was associated with age, length of service, and baseline IFN-γ levels, but not with the profession of the participant, degree of TB exposure, or wearing of an N95 mask. In five participants, fluctuations in ...Continue Reading

References

May 13, 2006·American Journal of Respiratory and Critical Care Medicine·Madhukar PaiDick Menzies
Jun 27, 2006·American Journal of Respiratory and Critical Care Medicine·Katie EwerAjit Lalvani
Jun 15, 2007·PLoS Medicine·Philip C HillKeith P McAdam
Aug 21, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nira R PollockEdward Nardell
Apr 4, 2009·American Journal of Respiratory and Critical Care Medicine·Richard N van Zyl-SmitKeertan Dheda
Jul 30, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·C B E CheeY T Wang
Oct 24, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kwangha LeeTae Sun Shim
Jun 4, 2010·Journal of Clinical Microbiology·Victor HerreraNiaz Banaei
May 20, 2011·Clinical and Vaccine Immunology : CVI·Felix C RingshausenGernot Rohde
Jan 13, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S Rafiza, K G Rampal

❮ Previous
Next ❯

Citations

Sep 13, 2012·PloS One·William C WhitworthGerald H Mazurek
Jan 28, 2014·PloS One·William C WhitworthGerald H Mazurek
Jan 23, 2014·Annals of the American Thoracic Society·Manish JoshiGail L Woods
Oct 10, 2014·Current Respiratory Care Reports·Anna K PersonTimothy R Sterling
Jan 7, 2016·Expert Review of Molecular Diagnostics·Matthew Bates, Alimuddin Zumla
Dec 7, 2013·Expert Opinion on Biological Therapy·Rosita SaracenoSergio Chimenti
Dec 5, 2012·Chest·Deepak AggarwalPrasanta Raghab Mohapatra
Sep 6, 2012·Chest·Alkesh K Khurana, Ujjawal Khurana
Mar 13, 2016·Survey of Ophthalmology·Ae Ra KeeRupesh Agrawal
Jan 7, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kwang-Sook WooKyeong-Hee Kim
Jul 20, 2016·Tuberculosis and Respiratory Diseases·Jeong Ha Mok
Nov 3, 2015·Annals of Laboratory Medicine·Kwang Sook WooKyeong Hee Kim
Aug 26, 2014·Journal of the International Association of Providers of AIDS Care·Andrea T CruzJeffrey R Starke
Nov 18, 2017·PloS One·Young KimSeung Heon Lee
Aug 30, 2013·Clinical and Vaccine Immunology : CVI·Tamara Tuuminen
Jan 8, 2014·Clinical Microbiology Reviews·Madhukar PaiNiaz Banaei
Jan 26, 2017·Tuberculosis and Respiratory Diseases·Kyung-Wook Jo
Oct 6, 2020·Frontiers in Immunology·Claudia CarranzaMartha Torres

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.