Mood disorder symptoms and elevated cardiovascular disease risk in patients with bipolar disorder.

Journal of Affective Disorders
Juliette M SlomkaAmy M Kilbourne

Abstract

We examined the association between mood symptoms and 10-year CVD risk estimated by Framingham risk score in a cohort of patients with bipolar disorder. Veterans with bipolar disorder and CVD risk factors (N=118) were recruited from outpatient VA clinics. CVD risk factor data were collected from electronic medical records and patient surveys, and used to calculate patient Framingham Scores. The relationship between mood symptoms (depressive, manic) and Framingham scores was examined, as was the relationship between mental health symptoms and individual CVD risk factors (lipids, blood pressure, weight, smoking, and fasting glucose). Mean sample age was 53 years (SD=9.9), 17% were female, and 5% were African-American. Almost 70% were obese (BMI≥30), 84% had hyperlipidemia, 70% were hypertensive, and 25% had diabetes. Nineteen percent had a Framingham score of >20%, indicative of elevated 10-year risk of developing CVD. After adjusting for age, gender, diabetes diagnosis, smoking status, and mood symptoms, patients with clinically significant depressive symptoms had a 6-fold increased odds of having a Framingham score of >20% (OR=6.1, p=0.03) while clinically significant manic symptoms were not associated with the Framingham score...Continue Reading

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Citations

Aug 10, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·S PiniA Balbarini
Apr 22, 2015·General Hospital Psychiatry·Jer-Hwa HsuChing-Heng Lin
Jan 4, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·A VoggtE Severus
Dec 4, 2012·Atencion primaria·Quintí Foguet BoreuUNKNOWN en representación del grupo de Riesgo Cardiovascular en Trastorno Mental Severo (RISCA-TMS)
Nov 5, 2016·Journal of Affective Disorders·R IcickUNKNOWN FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators
Dec 5, 2017·Indian Journal of Psychological Medicine·Swetha Reddy Damegunta, Prasad Rao Gundugurti
May 20, 2017·Psychiatry and Clinical Neurosciences·Shang-Ying TsaiWen-Cheng Wu
Jul 14, 2020·Journal of Affective Disorders·Michele Lima GregórioMoacir Fernandes de Godoy
Jul 25, 2021·Translational Psychiatry·Linn RødevandOle A Andreassen

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