Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study

Arthritis & Rheumatology
John G HanlyV Farewell

Abstract

To examine the frequency, characteristics, and outcome of mood disorders, as well as clinical and autoantibody associations, in a multiethnic/racial, prospective inception cohort of patients with systemic lupus erythematosus (SLE). Patients were assessed annually for mood disorders (4 types, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and Short Form 36 subscales, mental and physical component summary scores were collected. Time to event, linear and ordinal regressions, and multi-state models were used as appropriate. Among the 1,827 patients with SLE, 88.9% were female, and 48.9% were Caucasian. The mean ± SD age of the patients was 35.1 ± 13.3 years, disease duration was 5.6 ± 4.8 months, and the length of followup was 4.7 ± 3.5 years. During the course of the study, 863 (47.2%) of the 1,827 patients had 1,627 neuropsychiatric events. Mood disorders occurred in 232 (12.7%) of 1,827 patients, and 98 (38.3%) of 256 mood disorder events were attributed to...Continue Reading

References

Jul 24, 1996·JAMA : the Journal of the American Medical Association·M M WeissmanE K Yeh
Oct 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·J L Ayuso-MateosUNKNOWN ODIN Group
Jun 28, 2003·International Journal of Methods in Psychiatric Research·Laura AndradeHans-Ulrich Wittchen
Nov 4, 2006·Lupus·D IsenbergUNKNOWN SLICC Group
Dec 30, 2006·Arthritis and Rheumatism·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics
Mar 4, 2008·Arthritis and Rheumatism·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics
Apr 29, 2008·Arthritis and Rheumatism·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics
Jan 30, 2009·Arthritis and Rheumatism·Laura J JulianPatricia Katz
Apr 11, 2009·Annals of the Rheumatic Diseases·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics (SLICC)
Jun 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Vibeke Strand, Bruce Crawford
Feb 24, 2011·Annals of the Rheumatic Diseases·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics (SLICC)
Jun 5, 2012·The Journal of Rheumatology·John G HanlyJohn D Fisk
Aug 17, 2014·The Journal of Rheumatology·Xiangyang HuangMichelle Petri

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Citations

Jun 17, 2016·Nature Reviews. Disease Primers·Arvind KaulGraham Hughes
Jul 28, 2016·Epidemiology and Psychiatric Sciences·S TiosanoD Amital
Nov 20, 2018·Lupus·M Lynall
Jun 22, 2018·Arthritis & Rheumatology·John G HanlyJulius Birnbaum
Jan 12, 2019·Expert Review of Clinical Immunology·Jaqueline Cristina de AmorimSimone Appenzeller
Oct 26, 2018·Arthritis Care & Research·David S PisetskyJennifer L Rogers
Sep 27, 2018·Current Rheumatology Reviews·Andrew KwanZahi Touma
Dec 31, 2019·Journal of Immunology Research·Mohammed AlghamdiElrashdy M Redwan
Jun 22, 2018·Frontiers in Immunology·Sarah McGlassonDavid P J Hunt
Jun 19, 2019·Journal of Clinical Medicine·Warren David RaymondJohannes Cornelis Nossent
Nov 13, 2018·Current Rheumatology Reports·Annaliese TisseverasingheCarol Hitchon
Jun 4, 2020·Continuum : Lifelong Learning in Neurology·Pantelis P Pavlakis
Nov 21, 2020·Lupus Science & Medicine·Philippe MertzLaurent Arnaud
Feb 4, 2021·Journal of Immunology Research·Shangzhu ZhangXiaofeng Zeng
Feb 21, 2021·Autoimmunity Reviews·Irene Carrión-BarberàJordi Monfort
Mar 9, 2021·Expert Review of Clinical Immunology·Dionysis NikolopoulosGeorge Bertsias
Apr 10, 2021·Journal of the Neurological Sciences·John G Hanly, Murat Inanç

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