PMID: 2492164Jan 1, 1989Paper

Mood disorders in the psychoneurologic borderland: three cases of responsiveness to carbamazepine

The American Journal of Psychiatry
A J KesslerJ W Jefferson

Abstract

Three patients with affective disorders with psychotic features were refractory to various combinations of psychotropic agents (antipsychotics, antidepressants, and lithium). Closer scrutiny revealed a seizure history in two patients and unusual neuropsychiatric features in the third patient. Subsequent substitution of carbamazepine for the antipsychotic resulted in control of the patients' psychoses. The authors describe clinical features that may identify the patient who may respond to carbamazepine. The mechanism of carbamazepine's psychotropic effects through its hypothesized ability to inhibit limbic system kindling is discussed. The case reports emphasize the need for careful neuropsychiatric assessment of patients who are refractory to conventional treatments.

Citations

May 29, 2007·Medical Hypotheses·Iria Alvarez-SilvaAntonio Campayo-Martínez
Feb 1, 1990·Archives of Psychiatric Nursing·G W McEnany
Mar 1, 1992·General Hospital Psychiatry·E M Kahn
Nov 1, 1992·Comprehensive Psychiatry·J A BourgeoisM J Hall
May 3, 2014·The Cochrane Database of Systematic Reviews·Stefan LeuchtJohn McGrath
Jun 1, 1996·The Psychiatric Clinics of North America·A J Rothschild
Nov 10, 2020·Psychotherapy and Psychosomatics·Steven L DubovskyVictoria Cranwell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here