Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior

Brain, Behavior, and Immunity
Julie LasselinSven Benson

Abstract

Lipopolysaccharide (LPS) administration is a well-established model to assess afferent immune-to-brain communication and behavioral aspects of inflammation. Nevertheless, only few studies in comparatively small samples have assessed state anxiety as a psychological component of sickness behavior despite possible clinical implications for the pathophysiology of neuropsychiatric conditions. Thus, the goal of the present analyses carried out in a large, pooled dataset from two independent study sites was to analyze the state anxiety response to LPS administration and to investigate predictors (i.e., cytokine changes; pre-existing anxiety and depression symptoms assessed with the Hospital Anxiety and Depression Scale) of the LPS-induced state anxiety changes at different time points after LPS administration. Data from 186 healthy volunteers who participated in one of six randomized, placebo-controlled human studies involving intravenous administration of LPS at doses of 0.4-0.8ng/kg body weight were combined. State anxiety as well as circulating interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-10 concentrations were significantly increased 2h and 3h after LPS administration, with a peak at 2h, and returned to baseline 6h af...Continue Reading

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Citations

Mar 31, 2016·The International Journal of Neuropsychopharmacology·Jennifer L Remus, Robert Dantzer
Aug 18, 2016·Brain, Behavior, and Immunity·Neil A Harrison
Sep 14, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julie LasselinMats Lekander
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Jul 7, 2021·Translational Psychiatry·Annica J RasmussonJanet L Cunningham

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