Mood sensitivity to estradiol predicts depressive symptoms in the menopause transition.

Psychological Medicine
Jennifer L GordonLaurie Sykes Tottenham

Abstract

The risk for depression markedly rises during the 5-6 years leading up to the cessation of menstruation, known as the menopause transition. Exposure to extreme estradiol levels may help explain this increase but few studies have examined individual sensitivity to estradiol in predicting perimenopausal depression. The current study recruited 101 perimenopausal women. During Phase 1, we quantified each woman's sensitivity to changes in estradiol using 12 weekly measures of estrone-3-glucuronide (E1G), a urinary metabolite of estradiol, and concurrent depressive symptoms. The weekly cortisol awakening response was measured to examine the hypothalamic-pituitary-adrenal (HPA) axis in mediating mood sensitivity to estradiol. In Phase 2, depressive symptoms and major depression diagnoses were assessed monthly for 9 months. The relationship between Phase 1 E1G sensitivity and Phase 2 depressive symptoms and major depressive episodes was examined. Several baseline characteristics were examined as potential moderators of this relationship. The within-person correlation between weekly E1G and mood varied greatly from woman to woman, both in strength and direction. Phase 1 E1G mood sensitivity predicted the occurrence of clinically signifi...Continue Reading

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Citations

Jan 26, 2021·Psychoneuroendocrinology·Anouk E de WitHadine Joffe
Jan 6, 2021·Menopause : the Journal of the North American Menopause Society·Jasmine WilliUlrike Ehlert
Mar 7, 2021·Psychoneuroendocrinology·Hannah SüssUlrike Ehlert
Mar 25, 2021·Climacteric : the Journal of the International Menopause Society·M T WeberP M Maki
Jun 12, 2021·Biology of Sex Differences·Ashley R EthierJennifer L Gordon
Aug 1, 2021·Biology of Sex Differences·Bethany SanderJennifer L Gordon
Oct 7, 2021·Current Psychiatry Reports·Bethany Sander, Jennifer L Gordon

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