Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability

The International Journal of Neuropsychopharmacology
G ChenH K Manji

Abstract

Manic depressive illness (MDI) is a common, severe, chronic and often life-threatening illness. Despite well-established genetic diatheses and extensive research, the biochemical abnormalities underlying the predisposition to, and the pathophysiology of, these disorders remain to be clearly established. Despite formidable obstacles in our attempts to understand the underlying neurobiology of this illness, there is currently considerable excitement about the progress that is being made using novel strategies to identify changes in gene expression that may have therapeutic relevance in the long-term treatment of MDI. In this paper, we describe our recent research endeavours utilizing newer technologies, including a concerted series of mRNA RT-PCR studies, which has led to the identification of novel, hitherto completely unexpected targets for the long-term actions of mood stabilizers - the major cytoprotective protein bcl-2, a human mRNA binding (and stabilizing) protein, AUH, and a Rho kinase. These results add to the growing body of data suggesting that mood stabilizers may bring about some of their long-term benefits by enhancing neuroplasticity and cellular resilience. These results are noteworthy since recent morphometric br...Continue Reading

Citations

Mar 12, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Timothy W CorsonJerry J Warsh
May 11, 2010·Neuropsychobiology·Jorge A QuirozHusseini K Manji
Oct 3, 2008·Proteins·Kazuki KurimotoShigeyuki Yokoyama
Dec 20, 2003·Annals of the New York Academy of Sciences·Carlos A ZarateHusseini K Manji
Jan 16, 2013·Depression Research and Treatment·Yasuko KitagishiSatoru Matsuda
Dec 15, 2004·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Flávio KapczinskiVanessa Zannatto
May 12, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A V ProninO A Gromovа

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