Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease.

BMC Infectious Diseases
G Iyer ParameswaranSanjay Sethi

Abstract

Moraxella catarrhalis causes approximately 10% of exacerbations in chronic obstructive pulmonary disease (COPD) and also colonizes the lower airway in stable patients. Little is known about the effects of colonization by M. catarrhalis on airway inflammation and protease-antiprotease balance, and how these changes compare to those seen during exacerbations. Since COPD is a progressive inflammatory disease, elucidating the effects of bacterial colonization and exacerbation on airway inflammation is relevant to understanding disease progression in COPD. Our aims were (1) Analyze changes in airway inflammation in colonization and exacerbation of COPD due to M. catarrhalis; (2) Explore protease-antiprotease balance in colonization and exacerbation due to M. catarrhalis. Our hypothesis were (1) Acquisition of a new strain of M. catarrhalis in COPD increases airway inflammation from baseline and alters the protease-antiprotease balance towards a more proteolytic environment; (2) These changes are greater during exacerbations associated with M. catarrhalis as compared to colonization. Thirty-nine consecutive COPD patients with 76 acquisitions of a new strain of M. catarrhalis over a 6-year period were identified in a prospective study...Continue Reading

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Citations

Oct 2, 2012·American Journal of Respiratory and Critical Care Medicine·Patrick MalliaSebastian L Johnston
Dec 4, 2012·American Journal of Respiratory and Critical Care Medicine·Sanjay Sethi
Jan 19, 2013·American Journal of Respiratory Cell and Molecular Biology·Kim Hoenderdos, Alison Condliffe
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Methods Mentioned

BETA
ELISA
acetylation
bronchoalveolar lavage
Enzyme linked immunosorbent assay

Software Mentioned

it
Analyse
Excel

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