PMID: 9173208Mar 15, 1997Paper

Moraxella catarrhalis: virulence and resistance mechanisms

Medizinische Klinik
W Cullmann

Abstract

It is more than a century ago that Moraxella catarrhalis was discovered and described in some detail. However, it was not until the last decade that M. catarrhalis was recognized as a facultative pathogen, namely in otitis media (predominantly in children), sinusitis and nosocomial pneumonia in the group of elderly, debilitated patients. Liberation of endotoxin, histamine, and chemotactically active factors can be considered the major pathogenicity factors. The pathogen can protect itself, on the one hand by binding of the Clq subcomponent of the complement system followed by subsequent formation of a functionally inactive complex with Cl, and on the other hand by inactivation of the terminal (lytic) complement complexes by means of a specific protein on the surface of the outer cell wall. Routine diagnostic procedures require, above all, culture of the pathogen: up to now the detection of specific IgA-antibodies has not been routinely available. More than half of the clinical isolates are known to exhibit beta-lactamase production (BRO-enzymes). This is the reason why combinations of a penicillin compound with a beta-lactamase inhibitor, the group of the newer cephalosporins (including the orally active ones), doxycycline and ...Continue Reading

References

Jan 1, 1976·Scandinavian Journal of Infectious Diseases·J E BrorsonS E Holm
Nov 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F H KayserP Santanam
May 14, 1990·The American Journal of Medicine·P W WrightJ R Shepherd
Nov 1, 1990·The Journal of Infectious Diseases·A VergheseB W Franzus
Apr 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H Schønheyder, T Ejlertsen
May 1, 1989·Journal of Clinical Pathology·J L DevaliaR J Davies
Mar 1, 1989·Canadian Journal of Microbiology·A B Schryvers, B C Lee
May 1, 1988·The Annals of Otology, Rhinology & Laryngology. Supplement·W F DivenB Vietmeier
Jun 1, 1988·Infection and Immunity·J H Shaw, S Falkow
May 1, 1988·The Annals of Otology, Rhinology & Laryngology. Supplement·T F DeMaria
Apr 1, 1986·Antimicrobial Agents and Chemotherapy·E YokotaS Mitsuhashi
May 1, 1985·The Journal of Infectious Diseases·A J ChapmanR J Wallace
Sep 1, 1983·Reviews of Infectious Diseases·P F Sparling
Jan 1, 1983·Scandinavian Journal of Infectious Diseases·M MalkamäkiP H Mäkelä
Feb 1, 1983·The Journal of Pediatrics·A L KovatchR H Michaels
Jan 1, 1984·The Journal of Antimicrobial Chemotherapy·E E StobberinghC P van Boven
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·C KammeS Ståhl
Mar 1, 1982·Antimicrobial Agents and Chemotherapy·T Farmer, C Reading
Dec 1, 1981·The Journal of Infectious Diseases·M LeinonenP H Mäkelä

❮ Previous
Next ❯

Related Concepts

Related Feeds

Beta-lactamase Inhibitors (ASM)

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Beta-lactamase Inhibitors

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
K McGregorThomas V Riley
Clinical Microbiology Reviews
Cees M VerduinAlex van Belkum
Southern Medical Journal
W M AbuhammourA S Dajani
© 2021 Meta ULC. All rights reserved