Morbid obesity and hypertension: The role of perirenal fat.

The Journal of Clinical Hypertension
Maria Anastasia RicciGraziana Lupattelli

Abstract

Accumulation of fat in renal sinus and hilum is associated with hypertension development. We evaluated the relationship between perirenal fat and hypertension in a population of morbidly obese patients and the potential variations after sleeve-gastrectomy. Two hundred and eighty-four morbidly obese patients were included in the study, and 126 underwent sleeve-gastrectomy. At baseline and 10-12 months after surgery, we evaluated anthropometric parameters, blood pressure, glycometabolic, and lipidic assessment, and performed an ultrasonographic evaluation of visceral fat area and perirenal fat thickness. The perirenal fat thickness in hypertensive obese was higher than in nonhypertensive (13.6 ± 4.8 vs 11.6 ± 4.1, P = 0.001). It showed a significant direct correlation with age, waist circumference, BMI, systolic blood pressure (SBP), insulinemia, HOMA-IR, glycated hemoglobin, and creatinine. The independent predictors (R2  = 0.129) of SBP were perirenal fat thickness (β = 0.160, P = 0.022) and age (β = 0.175, P = 0.011). After surgery, perirenal fat thickness significantly decreased (from 13 ± 4 to 9 ± 4 mm, P <0.001). In the 89 hypertensive obese patients who underwent sleeve-gastrectomy, we observed a significant decrease in an...Continue Reading

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Citations

May 28, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken ChenDachun Yang
Oct 13, 2019·Scientific Reports·Marco D'AbbondanzaGraziana Lupattelli
Dec 2, 2020·Animals : an Open Access Journal From MDPI·Jiahao ShaoSongjia Lai
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Apr 4, 2021·Journal of Clinical Medicine·Adriana GrigorașCornelia Amalinei
Apr 6, 2021·Topics in Spinal Cord Injury Rehabilitation·David R GaterEduard Tiozzo
Dec 11, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Muhei TanakaMichiaki Fukui
Aug 20, 2021·Frontiers in Endocrinology·Safaa H HammoudAhmed F El-Yazbi

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