Morbid Obesity Increases the Risk of Postoperative Wound Complications, Infection, and Repeat Surgical Procedures Following Upper Extremity Limb Salvage Surgery for Soft Tissue Sarcoma

Hand : Official Journal of the American Association for Hand Surgery
Matthew T HoudekJ Wunder

Abstract

Obesity is a known risk factor for wound complications; however, unlike elective upper extremity procedures, where obesity can be modified preoperatively, excision of soft tissue sarcomas (STSs) is not elective, and as such, obesity cannot be modified. There is a paucity of data concerning the impact of obesity on wound healing in upper extremity sarcoma surgery. A total of 261 (159 males and 102 females) patients with a STS of the upper extremity from 2006-2014 were reviewed. The mean age and body mass index (BMI) were 56 (18-97) years and 26.6 (15.4-40.8) kg/m2, respectively. Sixty-nine patients (26%) were classified as obese (BMI ⩾30 kg/m2): class I (obese, BMI = 30-34.9 kg/m2; n = 48, 18%), class II (severely obese, BMI = 35.0-39.9 kg/m2; n = 16, 6%), and class III (morbidly obese, BMI ≥ 40 kg/m2; n = 5, 2%). Functional outcomes were also compared between obese and nonobese patients using the Musculoskeletal Tumor Society (MSTS) 1993 rating system and Toronto Extremity Salvage Scores (TESS). Forty-nine patients (19%) sustained a wound dehiscence, delayed healing, or infection. Class III obesity increased the risk of wound complications (hazard ratio [HR] = 8.19, 95% confidence interval [CI] = 1.96-22.96, P < .001) and infec...Continue Reading

References

Sep 1, 1991·Annals of Surgery·M F BrennanS I Hajdu
Apr 1, 1994·Plastic and Reconstructive Surgery·B G PeatF Langer
Oct 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A M DavisR S Bell
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L GuillouJ Costa
Mar 1, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T KunisadaP F M Choong
Feb 3, 2005·Obesity Research·Tatiana AndreyevaJeanne S Ringel
Apr 25, 2007·Clinical Orthopaedics and Related Research·David S GellerKevin A Raskin
Jan 13, 2009·The Journal of the American Academy of Orthopaedic Surgeons·Nathan F GilbertValerae O Lewis
Oct 29, 2010·Sarcoma·Brendan PrendergastDaniel J Indelicato
Oct 5, 2013·Journal of Shoulder and Elbow Surgery·Anil K GuptaGregory P Nicholson
Mar 8, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Michael Brian CrossCraig J Della Valle
Jun 7, 2014·Clinical Orthopaedics and Related Research·Vignesh K AlamandaGinger E Holt
Sep 19, 2014·The Journal of Bone and Joint Surgery. American Volume·Chad D WattsTad M Mabry
Dec 3, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J MooreS Mottard
Feb 20, 2015·The Journal of Bone and Joint Surgery. American Volume·Matthew T HoudekTad M Mabry
Apr 8, 2015·Clinical Orthopaedics and Related Research·Chad D WattsTad M Mabry
Feb 26, 2016·Journal of Shoulder and Elbow Surgery·Joseph M StatzJohn W Sperling
Feb 6, 2017·Journal of Shoulder and Elbow Surgery·Oke AnakwenzeAnshuman Singh
Feb 23, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J SlumpA C O'Neill
Jun 8, 2017·The Journal of Bone and Joint Surgery. American Volume·Eric R WagnerBassem T Elhassan

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Citations

Feb 7, 2020·Current Treatment Options in Oncology·Elyse J BrinkmannMatthew T Houdek
May 28, 2020·BMC Research Notes·Kazuhiko HashimotoMasao Akagi
Dec 18, 2020·Journal of Surgical Oncology·Yannick A J HoftiezerSantiago A Lozano-Calderón
Jul 15, 2020·Obesity Research & Clinical Practice·Abdulzahra HussainShamsi El-Hasani
Mar 20, 2021·Annals of Surgical Oncology·Gilber KaskIan Barner-Rasmussen
May 24, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Melissa E BarnesPaul F Ridgway
Aug 26, 2021·Journal of Surgical Oncology·Kiera LunnSantiago A Lozano-Calderón

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Methods Mentioned

BETA
surgical resections
amputations
amputation

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