PMID: 9165578Apr 1, 1997Paper

Morbidity after preoperative radiotherapy and cystectomy in patients with bladder cancer

Scandinavian Journal of Urology and Nephrology
R TomicH Modig

Abstract

The therapy-related morbidity was evaluated in 121 patients with muscle-invasive or recurrent superficial bladder cancer treated with radiotherapy and cystectomy. In 103 patients cystectomy succeeded 39-52 Gray (Gy) preoperative irradiation and in 18 patients cystectomy was done as a salvage procedure after previous full-dose radiotherapy. The overall frequency of complications was high; 71% of the patients treated with preoperative and 78% treated with full-dose radiotherapy had clinically relevant complications related to radiotherapy or surgery or both. The rate of intestinal complications was 39% for preoperative and 67% for full-dose radiotherapy. The overall mortality rate in intestinal complications was 3.3%. This study shows that the combination of radiotherapy and radical surgery in patients with bladder cancer is associated with a high rate of intestinal complications. The complications are significantly related to the irradiation dose and are long lasting and even life threatening.

References

Sep 1, 1989·The British Journal of Radiology·F C den Hartog JagerM van Haastert
Dec 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Duncan, P M Quilty
Jan 1, 1987·European Urology·O Lindell

❮ Previous
Next ❯

Citations

Oct 6, 2000·Urology·M R Feneley, M Schoenberg
Nov 30, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L Sengeløv, H von der Maase
Oct 19, 2010·The Journal of Urology·Manuel S EisenbergEila C Skinner
Jun 24, 2008·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Sanil Rege, Tim Lafferty
Mar 10, 2001·American Journal of Clinical Oncology·Z PetrovichL W Brady
Apr 14, 2009·Scandinavian Journal of Urology and Nephrology·Torvald GranforsBörje Ljungberg
Jul 1, 1998·Urologic Oncology·H TsujiiJ Shimazaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.