Morbidity and costs of salvage vs. primary radical prostatectomy in older men

Urologic Oncology
Sandip M PrasadJim C Hu

Abstract

Salvage radical prostatectomy (RP) is performed with curative intent following post-radiotherapy recurrence for prostate cancer. While single-center salvage RP outcomes appear promising, little is known about outcomes in the community setting in elderly men. We sought to evaluate utilization, outcomes, and costs of salvage RP vs. primary RP in older men. Surveillance, Epidemiology and End Results-Medicare linked data from 1992 to 2007 was used to identify 18,317 men aged 65 years or older who underwent RP from 2002 to 2007. Propensity score analyses were used to compare outcomes and costs for primary vs. salvage RP. Salvage RP was rare, accounting for 0.5% of RP. Men undergoing salvage vs. primary RP were older, white, and less likely to undergo CT, bone scan and prostate biopsy preoperatively (P < 0.05 for all). In adjusted analyses, salvage vs. primary RP was associated with increased 30-day complications (60.1% vs. 22.7%, P < 0.01), lengths of stay (mean 7 vs. 3 days, P < 0.01), and hospital readmissions within 30 days (30.4% vs. 5.7%, P < 0.01). The odds of death within 90 days were higher for salvage vs. primary RP (OR 26.7, 95% CI 12.9-55.1, P < 0.01). The median expenditure for salvage RP within 6 months postoperatively ...Continue Reading

References

Feb 12, 1998·Annals of Internal Medicine·D B Rubin
Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Nov 4, 2000·The Journal of Urology·A Vaidya, M S Soloway
Jan 9, 2001·Journal of Clinical Epidemiology·C N KlabundeJ L Warren
Apr 12, 2002·The New England Journal of Medicine·Colin B BeggPeter T Scardino
Jan 12, 2005·The Journal of Urology·Naji J ToumaJoseph L Chin
Mar 11, 2005·The Journal of Urology·John F WardHorst Zincke
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Fernando J BiancoJames A Eastham
Jul 15, 2005·Health Technology Assessment : HTA·A M GlennyUNKNOWN International Stroke Trial Collaborative Group
Aug 12, 2005·The Journal of Urology·Manfred JohannsenSerdar Deger
Feb 14, 2006·The Journal of Urology·Shira L GalperAnthony V D'Amico
Dec 1, 2007·Cancer·Piyush K AgarwalUNKNOWN Cancer of the Prostate Strategic Urological Research Endeavor (CaPSURE)
Dec 10, 2009·Journal of the National Cancer Institute·Nancy L KeatingMatthew R Smith
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Jan 23, 2016·Urologic Oncology·Oluwakayode AdejoroBadrinath Konety
Jun 10, 2015·European Urology·Giorgio GandagliaDavid C Miller

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