Morbidity and mortality due to cerebral edema complicating the treatment of severe leptospiral infection

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
A DavenportJ I Wyatt


Although neurological signs and symptoms are well described in leptospiral infections, cerebral edema has not been reported previously. We have encountered two patients with severe leptospiral infection, associated with multisystem involvement, who developed cerebral edema. Both patients were in acute oligoanuric renal failure, one being treated by acetate hemodialysis and the other by hemofiltration. Grand mal seizures developed in both patients, followed by respiratory, then cardiac arrest, as a consequence of dialytic therapy. Only one patient could be resuscitated and he was left with a hemiparesis. Cerebral edema may develop in patients with severe leptospiral infections consequent to treatments used in the management of renal failure.


Aug 1, 1979·The Journal of Pathology·T De BritoP H Yasuda
Dec 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A DavenportM S Losowsky
Jan 1, 1985·Annals of Biomedical Engineering·H A Kontos, E P Wei
Apr 1, 1984·Critical Care Medicine·E J QuebbemanW F Piering
Jun 1, 1980·Kidney International·V SitprijaS Boonpucknavig
Sep 1, 1953·Radiology·C M SILVERSTEIN
Jun 1, 1964·Archives of Internal Medicine·H PETERSON, A G SWANSON

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Mar 30, 2000·Infectious Disease Clinics of North America·A V LomarJ R Torres
Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·P O Williams
Mar 1, 1997·Renal Failure·R C Abdulkader

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