Morbidity and mortality in adults with idiopathic thrombocytopenic purpura.

Blood
J E PortieljeA Brand

Abstract

To study outcomes of adults with idiopathic thrombocytopenic purpura (ITP), we performed a follow-up study in a cohort of 152 consecutive patients who were treated according to a well-defined algorithm. Long-term outcomes were determined relative to the response 2 years after diagnosis, because most (93%) patients who ultimately attained platelet counts above 30.0 x 10(9)/L (30 000/microL) did so within this time frame. Complete follow-up for mortality could be studied in 99% of patients and for morbidity in 95% of patients, with a mean of 10.5 years. Within 2 years after diagnosis, 4 patients died, 2 were lost to follow-up, and 12 were reclassified as having secondary immune thrombocytopenia. Of the remaining 134 patients, 114 (85%) had obtained platelet counts above 30.0 x 10(9)/L while all therapies had been discontinued. These patients had a long-term mortality risk equal to the general population. Twelve of 134 patients (9%), all with severe thrombocytopenia, had refractory disease and suffered a mortality risk of 4.2 (95% confidence interval, 1.7-10.0). Bleeding and infection equally contributed to the death of these patients. Another 8 patients (6%) had platelet counts above 30.0 x 10(9)/L while on maintenance therapy. S...Continue Reading

References

Nov 1, 1978·The American Journal of the Medical Sciences·G G Shashaty, C E Rath
Sep 1, 1979·The Southeast Asian Journal of Tropical Medicine and Public Health·M J Larrieu
Jul 1, 1988·The American Journal of the Medical Sciences·T H GuthrieL M Prisant
Jan 1, 1984·Scandinavian Journal of Haematology·G J den OttolanderA Brand
Nov 1, 1980·The American Journal of Medicine·V J PicozziW P Creger
Jan 1, 1995·Acta Haematologica·M LinaresF Carbonell
May 1, 1995·The American Journal of Medicine·R StasiS Amadori
Nov 3, 1994·The New England Journal of Medicine·J N GeorgeG E Raskob
Oct 1, 1996·Surgical Endoscopy·R L FriedmanE H Phillips
Feb 15, 1997·Annals of Internal Medicine·R McMillan
Nov 17, 1998·American Journal of Surgery·R R Lozano-SalazarX López-Karpovitch

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Citations

Mar 22, 2006·Annals of Hematology·Francisco Javier PeñalverUNKNOWN Multi-institutional Retrospective Spanish Study Group on the Use of Rituximab in Refractory ITP
Mar 24, 2010·Annals of Hematology·Paula H B Bolton-Maggs, Victoria S L Kok
May 13, 2010·Annals of Hematology·Robert J Klaassen, Nancy L Young
Jul 1, 2006·Wiener klinische Wochenschrift·Klaus LechnerIngrid Pabinger
Mar 4, 2008·Journal of Thrombosis and Thrombolysis·Semir PasaOrhan Ayyildiz
Jun 3, 1999·Transfusion Science·M L Rand, J F Wright
Sep 18, 2012·International Journal of Technology Assessment in Health Care·Katy L CooperRon Akehurst
Aug 30, 2002·British Journal of Haematology·Drew Provan, Adrian Newland
Nov 13, 2001·Reviews in Clinical and Experimental Hematology·K Lechner
Aug 29, 2003·The New England Journal of Medicine·James N George, Sara K Vesely
Aug 29, 2003·The New England Journal of Medicine·Yunfeng ChengGregory Cheng
Mar 29, 2002·The New England Journal of Medicine·Douglas B Cines, Victor S Blanchette
Jun 30, 2011·Stem Cells and Development·Baijun FangYongping Song
Mar 7, 2003·Journal of Pediatric Hematology/oncology·James A Williams, Laurence A Boxer
Dec 12, 2003·Journal of Pediatric Hematology/oncology·Drew Provan, Adrian Newland
Oct 16, 2007·Current Opinion in Hematology·Patrick F Fogarty, Jodi B Segal
Oct 16, 2007·Current Opinion in Hematology·Bertrand GodeauJames Bussel
Sep 28, 2007·Current Opinion in Hematology·Nichola CooperRoberto Stasi
Jun 26, 2009·Current Opinion in Hematology·Adrian Newland
Jul 29, 2006·Journal of Clinical Pathology·W S A SmellieC Waine
Feb 17, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Emin KayaOzkan Ulutas
Mar 23, 2012·BMC Blood Disorders·T Michelle BrownChris L Pashos
Nov 19, 2011·PloS One·Axel C MatzdorffSimone Hummler
Mar 16, 2005·International Journal of Hematology·Kiarash Kojouri, James N George
Jun 3, 2011·Cleveland Clinic Journal of Medicine·Keith McCrae

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