Morbidity and mortality of vulvar and vaginal cancers: Impact of 2-, 4-, and 9-valent HPV vaccines

Human Vaccines & Immunotherapeutics
Tommy BuchananJennifer Young Pierce

Abstract

Vaginal and vulvar cancers do not account for a large proportion of gynecologic malignancies but their impact is significant. Both vaginal and vulvar lesions have precursors and display levels of dysplasia before progression to invasive disease. Human Papillomavirus (HPV) is a known causative agent of such dysplasia and can be detected now more readily than ever with adequate recognition techniques and provider awareness. Although HPV vaccination is still lagging compared to other recommended childhood vaccinations, the impact on lower genital tract neoplasia is promising. The bivalent and quadrivalent vaccines have been shown to be efficacious and the newest nonavalent vaccine should add even more of impact on coverage of cancer-causing HPV types. Although it is still early to show true clinical and population-based disease reduction due to low disease incidence and relatively short time of vaccine availability, the potential is noteworthy.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R KirnbauerJ T Schiller
Jan 1, 1992·American Journal of Obstetrics and Gynecology·M S HoffmanD Cavanagh
Nov 22, 2002·The New England Journal of Medicine·Laura A KoutskyUNKNOWN Proof of Principle Study Investigators
May 29, 2004·American Journal of Obstetrics and Gynecology·L Stewart MassadD Heather Watts
May 2, 2006·Obstetrics and Gynecology·Patricia L JudsonBeth A Virnig
May 15, 2007·The New England Journal of Medicine·UNKNOWN FUTURE II Study Group
May 15, 2007·The New England Journal of Medicine·Suzanne M GarlandUNKNOWN Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators
Nov 22, 2007·Gynecologic Oncology·Kevin A Ault
Dec 29, 2007·Journal of Lower Genital Tract Disease·L Stewart Massad
Dec 31, 2008·International Journal of Cancer. Journal International Du Cancer·Hugo De VuystSilvia Franceschi
Dec 2, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jonathan S Berek
Apr 5, 2011·Expert Opinion on Biological Therapy·Nathalie GarçonMarcelle Van Mechelen
Oct 23, 2012·The Journal of Infectious Diseases·Sepehr N TabriziSuzanne M Garland
Jan 1, 2013·Infectious Agents and Cancer·Beatriz SerranoSilvia de Sanjosé
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 6, 2013·American Journal of Obstetrics and Gynecology·Camille C GundersonKathleen N Moore
Jun 13, 2013·BMJ : British Medical Journal·Basil Donovan, Hammad Ali
Jul 28, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Silvia de SanjoséUNKNOWN HPV VVAP study group
Jul 31, 2013·American Journal of Obstetrics and Gynecology·J Alejandro Rauh-HainMarcela G del Carmen
Nov 22, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Edith M G van EschMariëtte I E van Poelgeest
Feb 13, 2014·JAMA : the Journal of the American Medical Association·Eva HerweijerLisen Arnheim-Dahlström
Aug 26, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Susan ZweizigJoanna M Cain
Aug 27, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L AlemanyUNKNOWN HPV VVAP study group
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Mahbubur RahmanAbbey B Berenson
Dec 6, 2014·Critical Reviews in Oncology/hematology·Angiolo GadducciClaudia Sergiampietri
Apr 8, 2015·International Journal of Women's Health·Ibrahim AlkatoutVeronika Günther

❮ Previous
Next ❯

Citations

Jun 4, 2017·International Journal of Cancer. Journal International Du Cancer·Mette T FaberFreija Verdoodt
Dec 1, 2017·Journal of Clinical Medicine·Uyen Ngoc MuiStephen K Tyring
Jul 1, 2017·F1000Research·Lai-Yang Lee, Suzanne M Garland
Mar 24, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Fabienne MicheliniKatawoura Beltako
Jan 30, 2019·Interdisciplinary Perspectives on Infectious Diseases·Lunthita M DuthelyJoNell E Potter
Jul 28, 2020·Vaccines·Liqin ChengJuan Du

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
dissection
biopsies
hysterectomy

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.