Morbidity, mortality and economic burden of renal impairment in cardiac intensive care

Internal Medicine Journal
D P ChewP Aylward

Abstract

Moderate to severe impairment of renal function has emerged as a potent risk factor for adverse short- and long-term outcomes among patients presenting with cardiac disease. We sought to define the clinical, late mortality and economic burden of this risk factor among patients presenting to cardiac intensive care. A clinical audit of patients presenting to cardiac intensive care was undertaken between July 2002 and June 2003. All patients presenting with cardiac diagnoses were included in the study. Baseline creatinine levels were assessed in all patients. Late mortality was assessed by the interrogation of the National Death Register. Renal impairment was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m2, as calculated by the Modified Diet in Renal Disease formula. In-hospital and late outcomes were compared by Cox proportional hazards modelling, adjusting for known confounders. A matched analysis and attributable risk calculation were undertaken to assess the proportion of late mortality accounted for by impairment of renal function and other known negative prognostic factors. The in-hospital total cost associated with renal impairment was assessed by linear regression. Glomerular filtration rate <60 mL/m...Continue Reading

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Citations

Aug 30, 2014·Journal of the American College of Cardiology·Vimal Ramjee
Feb 2, 2010·Mayo Clinic Proceedings·Ayman A El-MenyarDavid R Holmes
Aug 22, 2009·European Journal of Radiology·Daiji YoshikawaToyoaki Murohara
Apr 12, 2008·Journal of the American College of Cardiology·Peter A McCullough
Mar 18, 2011·Journal of Computer Assisted Tomography·Toyonari TakeuchiToyoaki Murohara
Apr 11, 2008·Critical Care Medicine·Peter A McCullough
Oct 2, 2012·Aging & Mental Health·Holly Dabelko-SchoenyJoseph Guada
Feb 3, 2011·Critical Care Nurse·Susan Dirkes
Jan 6, 2017·BMC Cardiovascular Disorders·I-Ting TsaiTeng-Hung Yu

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