Morbidity of lupus anticoagulants in children: a single institution experience

Thrombosis Research
Patricia CasaisMaria A Lazzari

Abstract

The lupus anticoagulant (LA) and the anticardiolipin antibodies (ACA) are the antiphospholipid antibodies more relevant clinically. Their clinical manifestations are diverse with most patients being asymptomatic while others present venous or arterial thrombosis, and more rarely, bleeding. Our objectives were to evaluate clinical presentation of LA in children and to correlate it to LA behavior. A retrospective cohort of patients (under 18 years old) who had a positive determination of LA followed by at least another determination of LA at a variable period was evaluated. Personal and family history, including infectious diseases temporally related to the event, were recorded. The screening of other coagulation disorders was performed according to symptoms, family history or laboratory results. Thirty-six patients were evaluated, median age was 10.8 years old, and 52.8% were female. Asymptomatic patients were 19.4% (7/36) of study population. Bleeding and thrombosis were found in 52.8% and 27.8%, respectively. Median LA determinations per patient were 3. von Willebrand disease was diagnosed in 66.7% of patients consulting for bleeding. A concomitant hemostatic defect was found in 8/10 patients with thrombosis (p = 0.003). LA be...Continue Reading

References

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Citations

Aug 2, 2006·Rheumatic Diseases Clinics of North America·Rolando Cimaz, Elodie Descloux
Nov 12, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Erdal PekerBaran Aydemir
Apr 1, 2008·Journal of Pediatric Hematology/oncology·Peter H ShawArthur Kim Ritchey
Mar 22, 2006·Acta Haematologica·Nick MerkelRosemarie Schobess

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