Morbidity, toxicity, and mortality classification systems in the local regional treatment of peritoneal surface malignancy

Journal of Surgical Oncology
Rami YounanMarcello Deraco

Abstract

To reach a consensus for reporting complications related to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Reporting the adverse events related to CRS + HIPEC is not standardized yet. Post-operative complications can be divided in two categories: the effects of surgical manipulation per se and the toxic effects of the heated intraoperative chemotherapy. Additive and/or synergistic effects also exist. Different centers have published their experience with regard to the complications associated with the procedure. Various classification systems have been used which makes a temptative comparison of the different techniques and results almost impossible. An effort was made here to review the existing major classification systems: The Bozzetti classification, the Clavien classification (and two proposed modifications from Feldman et al. and Elias et al.) and the Common terminology criteria for adverse events (CTCAE) version 3.0 of the National Institute of Health (NIH) criteria. A related document was sent to an international panel of experts. The CTCAE was adopted by the panel of experts as the unique classification system to be used for reporting complications related to CRS + HIPEC.

References

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Citations

Dec 16, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Wenceslao Vásquez JiménezSantiago González Moreno
Apr 16, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Álvaro Arjona-SánchezRosa Ortega-Salas
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May 28, 2014·Journal of Oncology·Horacio N López-BasaveAbelardo Meneses Garcia
Jul 31, 2013·Annals of Surgical Oncology·Anke M J KuijpersVic J Verwaal
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Sep 23, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C Seretis, H Youssef
Mar 28, 2013·World Journal of Surgery·Alvaro Arjona-SanchezSebastián Rufián-Peña
Feb 11, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Grace Hwei Ching TanMelissa Ching Ching Teo
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