MORC Proteins: Novel Players in Plant and Animal Health

Frontiers in Plant Science
Aline KochKarl-Heinz Kogel

Abstract

Microrchidia (MORC) proteins comprise a family of proteins that have been identified in prokaryotes and eukaryotes. They are defined by two hallmark domains: a GHKL-type ATPase and an S5 fold. MORC proteins in plants were first discovered via a genetic screen for Arabidopsis mutants compromised for resistance to a viral pathogen. Subsequent studies expanded their role in plant immunity and revealed their involvement in gene silencing and transposable element repression. Emerging data suggest that MORC proteins also participate in pathogen-induced chromatin remodeling and epigenetic gene regulation. In addition, biochemical analyses recently demonstrated that plant MORCs have topoisomerase II (topo II)-like DNA modifying activities that may be important for their function. Interestingly, animal MORC proteins exhibit many parallels with their plant counterparts, as they have been implicated in disease development and gene silencing. In addition, human MORCs, like plant MORCs, bind salicylic acid and this inhibits some of their topo II-like activities. In this review, we will focus primarily on plant MORCs, although relevant comparisons with animal MORCs will be provided.

References

Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·M L WatsonR W Moreadith
Jan 19, 2000·Trends in Biochemical Sciences·R Dutta, M Inouye
Feb 13, 2001·Trends in Cell Biology·P BurkhardS V Strelkov
Sep 25, 2003·Annual Review of Plant Biology·Gregory B MartinGuido Sessa
Apr 23, 2004·Trends in Plant Science·Kirankumar S Mysore, Choong-Min Ryu
Apr 20, 2005·Advances in Protein Chemistry·Andrei N Lupas, Markus Gruber
Jun 7, 2005·Genes & Development·Ana Losada, Tatsuya Hirano
Jun 9, 2005·Structure·Kevin D Corbett, James M Berger
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Adam RosendorffGrace Gill
Nov 17, 2006·Nature·Jonathan D G Jones, Jeffery L Dangl
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maud CondominesBernard Klein
Jul 5, 2007·British Journal of Haematology·Amanda P LigginsAlison H Banham
Apr 30, 2009·Annual Review of Phytopathology·A Corina VlotDaniel F Klessig
Jun 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·David A HubertJeffery L Dangl
Feb 10, 2010·Nature Reviews. Genetics·Julie A Law, Steven E Jacobsen
Mar 13, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Gui-Ling WangFeng Li
May 27, 2010·Journal of Cell Science·Yasuhiro MimuraNorimitsu Inoue
Apr 13, 2011·The Plant Journal : for Cell and Molecular Biology·Gudrun BöhmdorferDieter Schweizer
Apr 28, 2011·The EMBO Journal·Verena HoppmannRein Aasland
Jul 30, 2011·Science·UNKNOWN Arabidopsis Interactome Mapping Consortium
May 5, 2012·Science·Guillaume MoissiardSteven E Jacobsen
May 9, 2012·Current Biology : CB·Zdravko J LorkovićMarjori Matzke
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Robert H DowenJoseph R Ecker
Oct 18, 2012·Plant Signaling & Behavior·Zdravko J Lorković

❮ Previous
Next ❯

Citations

Mar 27, 2018·Plant Biotechnology Journal·Neelendra KumarJafargholi Imani
May 22, 2018·Molecular Plant-microbe Interactions : MPMI·Daniel F KlessigD'Maris Amick Dempsey
Jul 10, 2018·Genome Biology and Evolution·Wei DongLiangsheng Zhang
Feb 23, 2020·Clinical Genetics·Anna GrecoSilvère M van der Maarel
Jun 20, 2020·Journal of Experimental Botany·Ana Paula SantosSara Farrona
Jul 13, 2020·The Plant Journal : for Cell and Molecular Biology·Matthew WeissAmanda R De La Torre
Aug 21, 2020·Molecular Systems Biology·Jessica M BryantArtur Scherf
Apr 28, 2019·International Journal of Molecular Sciences·Steffi GoffartJaakko L O Pohjoismäki
Jul 10, 2019·Molecular Plant Pathology·Nathan MeierSavithramma P Dinesh-Kumar
Jun 17, 2020·Biochemical Society Transactions·Rachel M Woodhouse, Alyson Ashe
Sep 25, 2020·Journal of Experimental Botany·Shuai ZhangJian-Guo Wu
Oct 30, 2020·Molecular Microbiology·Leonardo AugustoWilliam J Sullivan
Nov 5, 2019·Journal of Psychiatric Research·Mara ThomasVanessa Nieratschker
Apr 15, 2021·Molecular Plant-microbe Interactions : MPMI
Aug 30, 2021·The New Phytologist·Adam Hannan ParkerJurriaan Ton

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
histone acetylation

Software Mentioned

Coffee
MyDomains

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.