Morcellation and the Incidence of Occult Uterine Malignancy: A Dual-Institution Review

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Toni M PicernoMark E Borowsky

Abstract

To determine the incidence of unsuspected uterine sarcoma (UtSarc), other uterine malignancies, and potential malignancies at the time of hysterectomy or myomectomy using power morcellation. We performed a retrospective cohort study of all women undergoing myomectomy or hysterectomy using power morcellation at 2 institutions between January 1, 2004, and May 31, 2015. The primary outcome was the incidence of uterine malignancy (UM). The predefined secondary outcome was the occurrence of other conditions associated with malignant behavior. For analysis, any UtSarc or endometrial cancer was categorized as a "uterine malignancy," whereas other pathologies with cytologic atypia were categorized as "uterine premalignant disease" (UPM). All other pathological results were classified as "nonmalignant." A total of 1004 women underwent hysterectomy or myomectomy using power morcellation during the studied period. Two women (1/502; 95% confidence interval [CI], 1/4144-1/139) were found to have UM pathology, 2 endometrial carcinomas and none with UtSarc (97.5% CI, 0-1/273). Six (1/167; 95% CI, 1/455-1/77) women were found to have UPM on final pathology: 2 atypical leiomyomas, 1 STUMP (smooth muscle tumors of uncertain malignant potential),...Continue Reading

References

May 16, 2006·Journal of Minimally Invasive Gynecology·Bernd BojahrRalf Ohlinger
Sep 5, 2006·The Oncologist·Alan C Schlaerth, Nadeem R Abu-Rustum
May 1, 2008·Gynecologic Oncology·Nisha BansalJason D Wright
Oct 12, 2012·Archives of Gynecology and Obstetrics·Juliane U ThebenDietmar Große-Drieling
Nov 29, 2012·PloS One·Michael A SeidmanBradley J Quade
Feb 21, 2013·JAMA : the Journal of the American Medical Association·Jason D WrightDawn L Hershman
Aug 22, 2013·Journal of Minimally Invasive Gynecology·Lobna OuldamerGilles Body
Jul 23, 2014·JAMA : the Journal of the American Medical Association·Jason D WrightDawn L Hershman
Mar 6, 2015·Gynecologic Oncology·Kerry GraebeBrian M Slomovitz
Mar 31, 2015·Archives of Gynecology and Obstetrics·Bernd BojahrGarri Tchartchian
May 9, 2015·Taiwanese Journal of Obstetrics & Gynecology·Kuan-Hung LinChi-Ling Chen
Aug 19, 2015·Gynecological Surgery·Elizabeth A PrittsDavid L Olive

❮ Previous
Next ❯

Citations

Dec 23, 2015·Archives of Gynecology and Obstetrics·Stefan RimbachFelix Offner
Mar 4, 2017·Journal of Minimally Invasive Gynecology·Megan WassonJavier Magrina
Dec 15, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Anais MalpicaEsther Oliva
Nov 29, 2017·Case Reports in Medicine·Harald Krentel, Rudy Leon De Wilde
Nov 13, 2017·Archives of Gynecology and Obstetrics·Marron WongKeith Isaacson
Apr 4, 2019·Updates in Surgery·Zaki SleimanAntonio Biondi
Nov 7, 2019·Journal of Obstetrics and Gynaecology of India·Garri TchartchianRudy L De Wilde
Jul 1, 2020·Female Pelvic Medicine & Reconstructive Surgery·Erica DavenportDavid L Howard
Nov 19, 2020·Gynecologic Oncology Reports·Tae-Kyu JangSo-Jin Shin
Feb 18, 2021·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists’ Committee on Gynecologic Practice
Sep 2, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Chen ZhangHonglan Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.