More advanced Alzheimer's disease may be associated with a decrease in cerebrospinal fluid pressure.

Cerebrospinal Fluid Research
Peter WostynPeter Paul De Deyn

Abstract

In a recent article, elevated cerebrospinal fluid pressure (CSFP) consistent with very early normal pressure hydrocephalus (NPH), was found in a small subset of Alzheimer's disease (AD) patients (possible AD-NPH hybrids) enrolled in a clinical trial for chronic low-flow cerebrospinal fluid drainage. Also in the same study, was another interesting finding that merits further discussion: a substantial proportion of AD patients had very low CSFP. Based on the characteristics of these subjects, we hypothesize that more advanced AD may be associated with a decrease in CSFP. Reduced CSFP among a group of AD patients could provide a clue towards a better understanding of the high rate of comorbidity reported between AD and glaucoma since it has been shown that mean CSFP is lower in subjects with primary open-angle glaucoma. This could result in an abnormally high trans-lamina cribrosa pressure difference and lead to glaucomatous damage.

References

Mar 27, 2002·European Neurology·A U BayerC Erb
Jan 1, 2003·Journal of Neurosurgery·Gerald D SilverbergEdward Rubenstein
Mar 28, 2006·Journal of the Neurological Sciences·Hiroki TamuraHiromu K Mishima
Jun 2, 2006·Cerebrospinal Fluid Research·Gerald SilverbergDawn McGuire
Jan 17, 2007·Journal of Glaucoma·Lars V KessingSven V Kessing
May 3, 2008·Ophthalmology·John P BerdahlDouglas H Johnson

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Citations

Jul 16, 2011·Clinical Ophthalmology·Fani TsolakiMagdalini Tsolaki
Jan 8, 2014·Progress in Retinal and Eye Research·Peter WostynPeter Paul De Deyn
Jan 9, 2010·Medical Hypotheses·Peter WostynPeter Paul De Deyn
Dec 23, 2015·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Peter WostynPeter Paul De Deyn
May 21, 2013·Annals of Neurology·Catherine HelmerCécile Delcourt
Sep 4, 2017·Journal of Neural Transmission·Tommaso SchirinziGiuseppe Sancesario

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