More chemistry in small spaces

Accounts of Chemical Research
Dariush Ajami, Julius Rebek

Abstract

This Account is about coaxing molecules into spaces barely big enough to contain them: encapsulation complexes. In capsules, synthetic modules assemble to fold around their molecular targets, isolate them from the medium for relatively long times, place them in a hydrophobic environment, and present them with functional groups. These arrangements also exist in the interior spaces of biology, and the consequences include the familiar features of enzymes: rapid reactions, stabilization of reactive intermediates, and catalysis. But inside capsules there are phenomena unknown to biology or historical chemistry, including new structures, new stereochemical relationships, and new reaction pathways. In encapsulation complexes, as in architecture, the space that is created by a structure determines what goes on inside. There are constant interactions between the container and contained molecules: encounters are not left to chance; they are prearranged, prolonged, and intense. Unlike architecture, these reversibly formed containers emerge only when a suitable guest is present. The components exist, but they cannot assemble without anything inside. Modifications of the capsule components give rise to the results of the present Account. T...Continue Reading

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Citations

Feb 9, 2013·Journal of the American Chemical Society·Jeffrey S MugridgeKenneth N Raymond
Nov 2, 2012·Organic Letters·Mónica Espelt, Pablo Ballester
Aug 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Simone MoscaJulius Rebek
Oct 13, 2015·Journal of the American Chemical Society·James J HenkelisJ Fraser Stoddart
Sep 12, 2015·Journal of the American Chemical Society·Sivil KopilevichIra A Weinstock
Nov 6, 2015·Journal of the American Chemical Society·Simone MoscaJulius Rebek
Jun 4, 2016·Journal of the American Chemical Society·Nai-Wei Wu, Julius Rebek
Jul 9, 2016·Nature Protocols·Simone MoscaJulius Rebek
Dec 10, 2016·The Journal of Organic Chemistry·Yu-Fei ZhangDietmar Kuck
Dec 20, 2016·The Journal of Organic Chemistry·Gerardo ConcilioCarlo Bertucci
Dec 21, 2016·Journal of the American Chemical Society·Haxel Lionel OzoresJuan R Granja
Aug 19, 2014·Nature Communications·Masahiro YamashinaMichito Yoshizawa
Jul 17, 2014·Chemical Society Reviews·Salvatore ZarraJonathan R Nitschke
Sep 4, 2015·Chemical Communications : Chem Comm·Chang-You ZhuWei Jiang
Nov 29, 2014·Chemical Communications : Chem Comm·L Catti, K Tiefenbacher
Oct 24, 2014·Chemical Society Reviews·Stefan H A M LeendersJoost N H Reek
Mar 29, 2018·Chemical Communications : Chem Comm·Khokan ChoudhuriPrasenjit Mal
Aug 18, 2017·Chemistry : a European Journal·Eline BartolamiSébastien Ulrich
Aug 12, 2014·Chemical Society Reviews·Liat Avram, Yoram Cohen
Apr 8, 2014·Chemical Society Reviews·Dariush AjamiJulius Rebek
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Jan 12, 2016·Chemical Communications : Chem Comm·Qing LiJing-Xin Liu
Aug 22, 2015·Chemical Communications : Chem Comm·Marina FukawaYoshio Kabe
Oct 18, 2014·Nature Communications·Kohei YazakiMichito Yoshizawa
Sep 19, 2017·Chemistry : a European Journal·Michael Å PetersenMichael Pittelkow
Sep 30, 2017·Chemistry : a European Journal·Wojciech DrożdżSébastien Ulrich
Jul 19, 2018·Chemical Communications : Chem Comm·Wei-Xu FengMihail Barboiu
Aug 30, 2018·Angewandte Chemie·Jian YangAlexandre Martinez
Sep 25, 2018·Angewandte Chemie·Nai-Wei WuJulius Rebek
Nov 28, 2018·Angewandte Chemie·Leslie-Joana RiwarFrançois Diederich
May 23, 2019·Chemical Communications : Chem Comm·Ankita KatiyarWard H Thompson
Mar 20, 2014·Chemistry : a European Journal·Achim Müller, Pierre Gouzerh
Jun 18, 2014·Chemical Communications : Chem Comm·Ranjan Dutta, Pradyut Ghosh
Feb 24, 2015·Nature Chemistry·Q Zhang, K Tiefenbacher
Mar 4, 2020·Physical Chemistry Chemical Physics : PCCP·Ankita KatiyarWard H Thompson

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