More optimal dose distributions for moving lung tumours: a planning study

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
B C John Cho, Tim Craig

Abstract

Target volumes for moving lung tumours encompass the full range of respiratory motion, increasing the risk of lung complications. Intensity modulated radiotherapy (IMRT) allows for more precise dose distributions. Distributions corresponding to the probability density function (PDF) of tumour motion may better spare lung yet deliver adequate target dose. The planning study purpose is to compare and evaluate different dose distributions on a moving lung tumour: (A) conformal RT (CRT) encompassing the full range of tumour motion, (B) CRT encompassing the modal tumour position only, and (C) an IMRT technique where the dose delivered corresponds to the tumour PDF. A 5 cm diameter spherical target within a rectangular lung equivalent phantom was treated using a parallel-opposed pair technique with a 1.5 cm margin around the tumour (in the beam's eye view). Asymmetrical sinusoidal (superior-inferior) target movement (peak-trough = 3 cm) was simulated for different dose distributions (prescription dose = 60 Gy). Equivalent uniform dose (EUD) for the tumour and normal tissue complication probabilities (NTCPs) for radiation pneumonitis were evaluated. The EUDs were 60.0, 48.5, and 57.9 Gy while the NTCPs were 5, 1, and 3% for cases A, B...Continue Reading

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Citations

Aug 15, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jian-Yue JinBenjamin Movsas
May 5, 2009·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Bodo ReitzMoyed Miften
Aug 16, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eric D Ehler, Wolfgang A Tomé
Sep 15, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Geert BosmansPhilippe Lambin
Feb 7, 2007·Medical Physics·Rojano KashaniJames Balter
Aug 29, 2019·Journal of Applied Clinical Medical Physics·Jeongmin YoonJong Min Park

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