PMID: 2114352Jul 1, 1990Paper

More precise localization of the gene for Hunter syndrome

Genomics
E Le GuernJ Boué

Abstract

A linkage analysis between the Hunter syndrome locus (IDS) and four polymorphic loci of the Xq27-Xq28 region, DXS105, DXS98, DXS304, and DXS52, was performed in large families. A significant lod score was obtained between DXS304 and the Hunter gene (Zmax = 6.57 at theta max = 0.0). The Hunter gene can be localized within 7 cM of this marker. In addition, the translocation breakpoint of the Hunter female case described by J. Mossman et al. (1986, Arch. Dis. Child. 58: 911-915) was localized between DXS98 and DXS304 using somatic cell hybrids. These two results are in agreement and give the following order: DXS105-DXS98-IDS-DXS304-DXS52. Probes for these marker loci can thus be used for carrier detection.

References

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Citations

Jan 8, 2003·The Journal of Gene Medicine·Youngtae HongSunyoung Kim
Jan 1, 1994·Prenatal Diagnosis·A H Fensom, P F Benson
Jun 1, 1995·International Journal of Pediatric Otorhinolaryngology·C W CremersW J Kimberling
Oct 21, 1998·International Journal of Pediatric Otorhinolaryngology·A YoskovitchV M Der Kaloustian
Sep 1, 1992·Nature Genetics·G DuykR F Mueller
Dec 1, 1995·Pediatric Dermatology·V V Panine, K Hashimoto
Jan 1, 1993·Developmental Medicine and Child Neurology·M Adinolfi

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