More than Decoration: Roles for Natural Killer Group 2 Member D Ligand Expression by Immune Cells

Frontiers in Immunology
Andrew P Trembath, Mary A Markiewicz

Abstract

The activating immune receptor natural killer group 2 member D (NKG2D), which is expressed by natural killer cells and T cell subsets, recognizes a number of ligands expressed by "stressed" or damaged cells. NKG2D has been extensively studied for its role in tumor immunosurveillance and antiviral immunity. To date, the majority of studies have focused on NKG2D-mediated killing of target cells expressing NKG2D ligands. However, with a number of reports describing expression of NKG2D ligands by cells that are not generally considered stressed, it is becoming clear that some healthy cells also express NKG2D ligands. Expression of these ligands by cells within the skin, intestinal epithelium, and the immune system suggests other immune functions for NKG2D ligand expression in addition to its canonical role as a "kill me" signal. How NKG2D ligands function in this capacity is just now starting to be unraveled. In this review, we examine the expression of NKG2D ligands by immune cells and discuss current literature describing the effects of this expression on immunity and immune regulation.

References

Feb 22, 2002·European Journal of Immunology·Leonidas N CarayannopoulosWayne M Yokoyama
Nov 12, 2002·Nature Immunology·Susan GilfillanMarco Colonna
Jan 18, 2003·Immunity·Kouetsu OgasawaraLewis L Lanier
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masahisa JinushiNorio Hayashi
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian A RabinovichRichard G Miller
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Veronika GrohThomas Spies
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masahisa JinushiNorio Hayashi
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica A HamermanLewis L Lanier
Mar 31, 2004·The Journal of Experimental Medicine·Konstantina ElemeDaniel M Davis
Jun 11, 2004·Immunity·Kouetsu OgasawaraLewis L Lanier
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David B RosenLewis L Lanier
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luciana L MolineroNorberto W Zwirner
Feb 1, 2005·European Journal of Immunology·Jennifer LiRichard G Miller
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren I Richie EhrlichLewis L Lanier
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin WiemannAlexander Steinle
Aug 9, 2005·Nature Immunology·Kouetsu OgasawaraLewis L Lanier
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary A MarkiewiczAndrey S Shaw
Dec 13, 2005·European Journal of Immunology·David SchramaJürgen C Becker
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monia DraghiPeter Parham
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akio TakadaMasanori Kasahara
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sugata RoyRamakrishna Vankayalapati
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mercedes KlossHelmut R Salih
Jul 25, 2009·Current Immunology Reviews·Robert A EagleAlexander D Barrow
May 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magali Noval RivasMichel Y Braun
Jun 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marine ChampsaurLewis L Lanier
Jun 12, 2010·Immunological Reviews·Marine Champsaur, Lewis L Lanier
Mar 29, 2011·Immunology·Deepak YadavJack D Bui
Apr 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily MartinezCatharina C Gross
May 25, 2011·International Journal of Cancer. Journal International Du Cancer·Maya Caroline AndréAlexander Steinle

❮ Previous
Next ❯

Citations

Oct 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Audrey PoupeauRomain Barrès
Feb 9, 2019·Expert Opinion on Therapeutic Targets·Mariya Lazarova, Alexander Steinle
Apr 23, 2019·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Mepur H RavindranathShahab Asgharzadeh
Jul 30, 2020·Expert Opinion on Biological Therapy·Mariya LazarovaAlexander Steinle
Aug 29, 2018·Frontiers in Immunology·Sam SheppardNadia Guerra
Nov 20, 2018·Melanoma Research·Vincas UrbonasVytautas Kasiulevicius
May 18, 2019·Blood Advances·Neekun Sharma, Mary A Markiewicz
May 12, 2019·Science Immunology·Rana NikzadSilke Paust
Sep 27, 2018·Frontiers in Immunology·Dominik Schmiedel, Ofer Mandelboim
Dec 6, 2019·Frontiers in Immunology·Mariya Lazarova, Alexander Steinle
Nov 28, 2020·Scientific Reports·Julia SpielmannHeike Kielstein
Jan 19, 2021·Oncoimmunology·Adeline RaynaudBrigitte Kerfelec

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
PMA
transgenic

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.