More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium

Frontiers in Cell and Developmental Biology
Angel DueñasD Franco

Abstract

The adult pumping heart is formed by distinct tissue layers. From inside to outside, the heart is composed by an internal endothelial layer, dubbed the endocardium, a thick myocardial component which supports the pumping capacity of the heart and exteriorly covered by a thin mesothelial layer named the epicardium. Cardiac insults such as coronary artery obstruction lead to ischemia and thus to an irreversible damage of the myocardial layer, provoking in many cases heart failure and death. Thus, searching for new pathways to regenerate the myocardium is an urgent biomedical need. Interestingly, the capacity of heart regeneration is present in other species, ranging from fishes to neonatal mammals. In this context, several lines of evidences demonstrated a key regulatory role for the epicardial layer. In this manuscript, we provide a state-of-the-art review on the developmental process leading to the formation of the epicardium, the distinct pathways controlling epicardial precursor cell specification and determination and current evidences on the regenerative potential of the epicardium to heal the injured heart.

References

Aug 1, 1990·Circulation·M L Kirby, K L Waldo
Feb 1, 1974·The Journal of Experimental Zoology·J O Oberpriller, J C Oberpriller
Mar 8, 1974·Nature·R O BeckerR Sherry
Aug 1, 1995·Circulation Research·M L Kirby, K L Waldo
Jun 16, 2001·Cells, Tissues, Organs·J MännerR Muñoz-Chápuli
Apr 5, 2002·Trends in Genetics : TIG·Robert G Kelly, Margaret E Buckingham
Dec 14, 2002·Science·Kenneth D PossMark T Keating
Dec 31, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·A Wessels, J M Pérez-Pomares
Jan 8, 2004·The Journal of Cell Biology·Sigolène M MeilhacMargaret E Buckingham
May 8, 2004·Developmental Cell·Sigolène M MeilhacMargaret E Buckingham
Jul 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christine M Liberatore, Katherine E Yutzey
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alistair J WattStephen A Duncan
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Esther MerkiPilar Ruiz-Lozano
Feb 4, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juan A GuadixJosé M Pérez-Pomares
Mar 11, 2006·Circulation Research·Robert J TomanekTakashi Mikawa
Jun 7, 2006·Developmental Biology·Boudewijn P T KruithofMaurice J B van den Hoff
Jun 9, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·José M Pérez-PomaresRamón Muñoz-Chápuli
Jul 28, 2006·PLoS Biology·Ching-Ling LienMark T Keating
Jan 24, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Inga SchulteJörg Männer
Mar 24, 2007·Cellular and Molecular Life Sciences : CMLS·E M Winter, A C Gittenberger-de Groot
Jan 22, 2008·Developmental Biology·Fabrizio C Serluca
Feb 26, 2008·Differentiation; Research in Biological Diversity·Heleen Lie-VenemaAdriana C Gittenberger-de Groot
Mar 4, 2008·The International Journal of Developmental Biology·Anna RatajskaBogdan Ciszek
Apr 19, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Kyoji UrayamaCanan G Nebigil
May 7, 2008·Trends in Molecular Medicine·Thomas E Callis, Da-Zhi Wang
May 16, 2008·Nature·Chen-Leng CaiSylvia M Evans
Mar 28, 2009·Circulation Research·Kimberly R Cordes, Deepak Srivastava
Apr 4, 2009·Science·Olaf BergmannJonas Frisén
Apr 17, 2009·Nature·Vincent M ChristoffelsAndreas Kispert
Aug 26, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Noortje A M BaxAdriana C Gittenberger-de Groot
Aug 29, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·José M IcardoValentín Sans-Coma

❮ Previous
Next ❯

Citations

Nov 14, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Justyna Niderla-BieliŃskaAnna Ratajska
Apr 4, 2019·Journal of Cardiovascular Development and Disease·Angel DueñasDiego Franco
Apr 13, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Daryl RamaiSarath Reddy
May 9, 2019·Genesis : the Journal of Genetics and Development·Suya Wang, Alexander R Moise
Sep 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laurent DésaubryCanan G Nebigil
May 1, 2021·Journal of Cardiovascular Development and Disease·Marietta EasterlingMichael Bressan
Nov 30, 2020·Archives of Biochemistry and Biophysics·Ariel SassonStephen J Peterson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Ching-Ling LienVaughn A Starnes
Pharmacology & Therapeutics
Federica LimanaAntonia Germani
Seminars in Cell & Developmental Biology
Jonathan LeorTal Konfino
Proceedings. Biological Sciences
Teresa Kennedy-Lydon, Nadia Rosenthal
© 2022 Meta ULC. All rights reserved