More than one way to skin . . .

Genes & Development
Elaine Fuchs, Valerie Horsley

Abstract

Epithelial stem cells in the skin are specified during development and are governed by epithelial-mesenchymal interactions to differentially adopt the cell fates that enable them to form the epidermis, hair follicle, and sebaceous gland. In the adult, each of three epithelial lineages maintains their own stem cell population for self-renewal and normal tissue homeostasis. However, in response to injury, at least some of these stem cell niches can be mobilized to repair an epithelial tissue whose resident stem cells have been damaged. How do these stem cell populations respond to multiple signaling networks, activate migration, and proliferation, and differentiate along a specific lineage? Recent clues add new pieces to this multidimensional puzzle. Understanding how these stem cells maintain normal homeostasis and wound repair in the skin is particularly important, as these mechanisms, when defective, lead to skin tissue diseases including cancers.

References

Jul 1, 1975·The Journal of Investigative Dermatology·I C Mackenzie
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y Barrandon, H Green
Jan 13, 1995·Cell·P H JonesF M Watt
Feb 15, 2003·Developmental Cell·Radhika AtitLee Niswander
Aug 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·C NiemannF M Watt
Nov 25, 2003·The American Journal of Pathology·Mary AllenAndrzej A Dlugosz
Dec 13, 2003·Science·Tudorita TumbarElaine Fuchs
Mar 17, 2004·Nature Biotechnology·Rebecca J MorrisGeorge Cotsarelis
Feb 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ruth Schmidt-Ullrich, Ralf Paus
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Jun 18, 2005·Genes & Development·William E LowryElaine Fuchs
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stéphanie ClaudinotYann Barrandon
Nov 1, 2005·Cancer Metastasis Reviews·C Brakebusch, R Fässler
Nov 5, 2005·Endocrinology·Zhongjian XieDaniel D Bikle
Dec 6, 2005·Developmental Cell·Vered LevyBruce A Morgan
Mar 3, 2006·Genes & Development·Xunwei WuCord Brakebusch
Mar 28, 2006·Nature Medicine·Hikaru TakedaFiona M Watt
May 6, 2006·The Journal of Investigative Dermatology·Nishit R TrivediDiane M Thiboutot
May 9, 2006·FEBS Letters·Joan Massagué, Roger R Gomis
Jul 1, 2006·Science·Horace RheeElaine Fuchs
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Cédric Blanpain, Elaine Fuchs
Aug 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kim B Jensen, Fiona M Watt
Sep 5, 2006·Developmental Cell·Gangwen HanXiao-Jing Wang
Nov 3, 2006·Genes & Development·Cédric BlanpainElaine Fuchs

❮ Previous
Next ❯

Citations

Dec 17, 2009·Expert Reviews in Molecular Medicine·Emoke Rácz, Errol P Prens
Jul 18, 2009·Cell Death and Differentiation·R Yi, E Fuchs
Jun 22, 2013·International Journal of Oral Science·John A Whitlock, Joy M Richman
Aug 22, 2012·Nature Reviews. Urology·Tomasz DrewaArun Sharma
May 13, 2011·The New England Journal of Medicine·Jan KajsturaPiero Anversa
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Katsuto TamaiYasufumi Kaneda
Jul 16, 2010·Stem Cells and Development·Sarah B Davies, Nick Di Girolamo
Jun 18, 2010·Plastic and Reconstructive Surgery·Björn BehrMichael T Longaker
Jan 14, 2011·Plastic and Reconstructive Surgery·Sae Hee KoMichael T Longaker
Jun 6, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jeff Donovan
Jul 2, 2008·Molecular and Cellular Biology·Yousang GwackAnjana Rao
Jun 23, 2012·PloS One·Manuel Rosa-GarridoAlberto Gandarillas
Jan 24, 2014·International Journal of Molecular Sciences·Pisal RishikayshJaroslav Mokry
Jul 9, 2013·Oncogene·M DrostenM Barbacid
Feb 12, 2014·Archives of Dermatological Research·Hiroshi MaruyamaYasuhiro Kawachi
Mar 26, 2014·Experimental and Molecular Pathology·Laurie B JosephJeffrey D Laskin
Feb 1, 2012·Stem Cell Reviews and Reports·Tudorita Tumbar
Mar 26, 2015·Growth Factors·Shienny SampurnoRobert G Ramsay
Oct 30, 2015·International Journal of Molecular Sciences·Nkemcho OjehOlivera Stojadinovic
Jul 4, 2012·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R ErozH Dogan
Aug 1, 2013·The Journal of Surgical Research·Madhuchhanda Roy, Timothy W King
Oct 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jessica A Lehoczky, Clifford J Tabin
Jan 30, 2013·Toxicology and Applied Pharmacology·Yoke-Chen ChangDonald R Gerecke
Sep 11, 2012·Seminars in Cell & Developmental Biology·Rachel Sennett, Michael Rendl
Sep 24, 2010·Kidney International·Jeremy S Duffield, Benjamin D Humphreys
Nov 10, 2010·Neurobiology of Disease·Jeremy M SullivanSharon Oleskevich
Aug 11, 2010·Trends in Molecular Medicine·Monique T BarakatMatthew P Scott
Jul 9, 2010·Urologic Oncology·Mireia Castillo-MartinCarlos Cordon-Cardo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.