Morin ameliorates the testicular apoptosis, oxidative stress, and impact on blood-testis barrier induced by photo-extracellularly synthesized silver nanoparticles

Environmental Science and Pollution Research International
Ahmed Hamed ArishaMohamed M A Hussein

Abstract

Silver nanoparticles (AgNPs) have been widely produced for different industrial purposes. Recently, biogenic synthesis of AgNPs has emerged although the extent of effects from exposure, oral exposure in particular, to nanomaterials synthesized in such a manner remains elusive. The main objective of this study was to evaluate the effects of oral administration of a dose of 50 mg/Kg body weight AgNPs biosynthesized in baker's yeast (Saccharomyces cerevisiae) over a period of eight weeks on the reproductive performance and the possibility of a protective effect through co-administration of morin. Forty-eight male Sprague-Dawley rats were used in four experimental groups (control, morin-treated group, AgNP-treated, and AgNP + morin co-treatment). AgNPs produced no significant alteration in daily food intake or body weight. Both the absolute and relative testicular weights were significantly reduced but not the epididymal weight. Also, serum levels of urea, creatinine, uric acid, and liver enzymes were significantly elevated. Furthermore, AgNPs significantly downregulated the hypothalamic-pituitary-gonadal axis. This corresponds to lower motility and viability percent, reduced sperm concentration, and a higher abnormality ratio as w...Continue Reading

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Citations

Mar 20, 2021·The Science of the Total Environment·Maingredy Rodrigues SouzaThiago Lopes Rocha
Apr 10, 2021·International Journal of Nanomedicine·Asmaa M ShehataPeter A Noshy
May 25, 2021·Toxicology Mechanisms and Methods·Samah A KhattabEman Ahmed Alaa El-Din
Jun 2, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ehsan H Abu-ZeidShereen El Abdel-Hamid
Jun 30, 2021·Journal of Complementary & Integrative Medicine·Ebenezer Tunde Olayinka, Kayode Ezekiel Adewole
Jun 19, 2021·Toxicology Research·Samah A KhattabEman Ahmed Alaa El-Din

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