Morin Attenuates Ovalbumin-Induced Airway Inflammation by Modulating Oxidative Stress-Responsive MAPK Signaling

Oxidative Medicine and Cellular Longevity
Yuan MaMao Huang

Abstract

Asthma is one of the most common inflammatory diseases characterized by airway hyperresponsiveness, inflammation, and remodeling. Morin, an active ingredient obtained from Moraceae plants, has been demonstrated to have promising anti-inflammatory activities in a range of disorders. However, its impacts on pulmonary diseases, particularly on asthma, have not been clarified. This study was designed to investigate whether morin alleviates airway inflammation in chronic asthma with an emphasis on oxidative stress modulation. In vivo, ovalbumin- (OVA-) sensitized mice were administered with morin or dexamethasone before challenge. Bronchoalveolar lavage fluid (BALF) and lung tissues were obtained to perform cell counts, histological analysis, and enzyme-linked immunosorbent assay. In vitro, human bronchial epithelial cells (BECs) were challenged by tumor necrosis factor alpha (TNF-α). The supernatant was collected for the detection of the proinflammatory proteins, and the cells were collected for reactive oxygen species (ROS)/mitogen-activated protein kinase (MAPK) evaluations. Severe inflammatory responses and remodeling were observed in the airways of the OVA-sensitized mice. Treatment with morin dramatically attenuated the extens...Continue Reading

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Citations

Nov 5, 2016·International Journal of Biological Macromolecules·Yuan LuXia Zhao
Jul 10, 2019·International Journal of Environmental Research and Public Health·Indhumathi VeerappanRajaguru Palanisamy
Mar 1, 2017·Frontiers in Immunology·Wen-Chung HuangChian-Jiun Liou
Feb 2, 2017·Respiratory Physiology & Neurobiology·Jingjing WangChangming Guo
Apr 17, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Gehan Hussein HeebaMohamed Montaser Khalifa
May 8, 2021·Journal of Cellular and Molecular Medicine·Jiapeng HuYunxiao Shang
Oct 27, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Peng QiDianbo Kou
Nov 6, 2021·Frontiers in Immunology·Fangzhou TengJingcheng Dong

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Methods Mentioned

BETA
bronchoalveolar lavage
lavage
enzyme-linked immunosorbent assay
MDA
ELISAs
electrophoresis
protein assay
ELISA
Fluorescence-activated
flow cytometry

Software Mentioned

SPSS
Prism
GraphPad
Quantity One

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