Morin augments anticarcinogenic and antiproliferative efficacy against 7,12-dimethylbenz(a)-anthracene induced experimental mammary carcinogenesis.

Molecular and Cellular Biochemistry
Ramadass NandhakumarSivasithambaram Niranjali Devaraj

Abstract

In general, oxidative stress resulting from an imbalance between prooxidant and antioxidant systems plays an important role in the pathogenesis of cancer. Morin (3,5,7,2',4'-pentahydroxyflavone), a member of the flavanol group, has been shown to possess chemopreventive potential against hepatocellular and colon cancer in experimental animals. Given the demonstrated importance of morin, aim of the present study was to evaluate the effect of morin on antiproliferative and anticarcinogenic effect against DMBA-induced experimental mammary carcinogenesis. Oral administration of 7,12-dimethylbenz(a)-anthracene (25 mg/kg body weight) to rats resulted in significant reduction of body weight, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase), and nonenzymic antioxidants (reduced glutathione, vitamin C, and vitamin E). The levels of lipid peroxidation markers (thiobarbituric acid reactive substances and hydroperoxides) and tumor markers such as CA 15-3, AFP and CEA in serum were increased significantly in cancer-induced animals as compared to control rats. Oral supplementation of morin at a dose of 50 mg/kg body weight significantly improved the body weight, enzymic, and nonenzymic a...Continue Reading

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Citations

Jun 13, 2020·Nutrition and Cancer·Solaipriya SolairajaSivaramakrishnan Venkatabalasubramanian
Apr 19, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Ayyakkannu PurushothamanThiruvaiyaru Panchanatham Sachidanandam
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Oct 12, 2017·Human & Experimental Toxicology·P BarnwalS Sultana
Dec 2, 2020·European Journal of Medicinal Chemistry·Ankur Kumar TanwarVikas Jaitak
Mar 22, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shahid Ali RajputHui-Chao Yan
Feb 7, 2013·Diabetology & Metabolic Syndrome·Hatem M AbuohashishMohammed M Ahmed

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