Morin exhibits leukemic cellular apoptosis through caspase pathway.

Natural Product Research
Wander Lopes PereiraLiovando Marciano da Costa

Abstract

The present study investigated the possibility of apoptosis-inducing activity in human leukemia U-937 and THP-1 cells by the flavonoid morin. The treatments were evaluated by using the MTT and LDH assays; analysis of mitochondrial membrane potential (ΔΨm) was evaluated by flow cytometry, cell death by apoptosis was confirmed by fluorescence microscopy and by assessing the activity of caspases-3 and -6. The data indicated that the flavonoid morin has promoted a decrease in cell viability in a concentration-dependent way for both of the cancerous cell lines. An increase in the percentage of cell death caused by apoptosis was associated to a potential alteration in the mitochondrial membrane (ΔΨm) suggesting the involvement of cell death in intrinsic apoptotic pathways. Activation of caspases-3 and -6 confirmed the presence of apoptotic activity from morin. The results reinforce the antileukemic potential of flavonol morin.

References

May 29, 2015·Current Medicinal Chemistry·Anna CaselliPaolo Paoli
Dec 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaofei ChengWeilin Wang
Dec 29, 2019·Food Research International·Iramaia Angelica Neri-NumaGlaucia Maria Pastore
Jan 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rafaela G A CostaDaniel P Bezerra

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