PMID: 8606614Jan 1, 1996Paper

Morin hydrate inhibits azo-initiator induced oxidation of human low density lipoprotein

Life Sciences
T W WuR D Weisel

Abstract

We demonstrated that the flavonoid morin hydrate at 75-100 microM protects against the oxidation of low density lipoprotein (LDL) by free radicals produced by 2,2'-azo-bis(2-amidinopropane) dihydrochloride. Morin hydrate reduces the relative electrophoretic mobility, malondialdehyde equivalents and lipid peroxide level of oxidized LDL. On the other hand, Trolox (an analogue of vitamin E) showed less protective effect in the present system. Since free radical mediated oxidation of LDL is implicated to be a cause of atherogenesis, morin hydrate may be a candidate chemotherapeutic agent herein.

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Citations

Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P C Hollman, M B Katan
Mar 22, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shahid Ali RajputHui-Chao Yan

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