Morin Prevents Granule Cell Dispersion and Neurotoxicity via Suppression of mTORC1 in a Kainic Acid-induced Seizure Model

Experimental Neurobiology
Ji Min LeeSang Ryong Kim

Abstract

An abnormal reorganization of the dentate gyrus and neurotoxic events are important phenotypes in the hippocampus of patients with temporal lobe epilepsy (TLE). The effects of morin, a bioflavonoid constituent of many herbs and fruits, on epileptic seizures have not yet been elucidated, though its beneficial effects, such as its anti-inflammatory and neuroprotective properties, are well-described in various neurodegenerative diseases. In the present study, we investigated whether treatment with morin hydrate (MH) can reduce the susceptibility to seizures, granule cell dispersion (GCD), mammalian target of rapamycin complex 1 (mTORC1) activity, and the increases in the levels of apoptotic molecules and inflammatory cytokines in the kainic acid (KA)-induced seizure mouse model. Our results showed that oral administration of MH could reduce susceptibility to seizures and lead to the inhibition of GCD and mTORC1 activity in the KA-treated hippocampus. Moreover, treatment with MH significantly reduced the increased levels of apoptotic signaling molecules and pro-inflammatory mediators in the KA-treated hippocampus compared with control mice, suggesting a neuroprotective role. Therefore, these results suggest that morin has a therape...Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Dec 12, 2001·Alimentary Pharmacology & Therapeutics·J GálvezA Zarzuelo
Jul 30, 2002·Progress in Brain Research·Tallie Z BaramRoland A Bender
Jun 15, 2005·Molecular Neurobiology·Qun WangAlbert Y Sun
Sep 20, 2005·The Journal of Pharmacology and Experimental Therapeutics·Zhifeng YuChristopher H K Cheng
Jun 23, 2006·Brain & Development·Daisuke TokuharaTsunekazu Yamano
Jun 30, 2006·Neurobiology of Disease·Miroslav GottliebCarlos Matute
Mar 21, 2007·Biochemical Society Transactions·D C Henshall
May 17, 2007·Epilepsy Currents·Annamaria Vezzani, Tallie Z Baram
May 24, 2007·Epilepsy Currents·Luisa L RochaClaude G Wasterlain
Jun 16, 2007·Epilepsia·Asla PitkänenJari Nissinen
Jul 30, 2008·Biochimica Et Biophysica Acta·Tzi-Wei LianMing-Jiuan Wu
Nov 18, 2008·Experimental Neurology·Robert F HuntBret N Smith
Mar 17, 2009·Journal of Neuropathology and Experimental Neurology·Katja KobowIngmar Blümcke
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ling-Hui ZengMichael Wong
Dec 31, 2009·Clinical Neuropathology·G MarucciM Giulioni
Mar 31, 2010·The Journal of Endocrinology·Jiyeon LeeSeungjoon Park
Jul 8, 2010·Journal of Clinical Neurology·Eun-Kee BaeJae-Kyu Roh
Jul 21, 2010·Acta Pharmacologica Sinica·Zhen-tao ZhangTao Wang
Dec 8, 2010·Nature Reviews. Neurology·Annamaria VezzaniTallie Z Baram
Mar 1, 2011·Neuroscience Letters·Sharon S McDaniel, Michael Wong
Mar 3, 2011·Neuroscience Letters·Teresa RavizzaAnnamaria Vezzani
Jun 19, 2013·Journal of the Neurological Sciences·Xiang-Fei MengLan Tan
Feb 15, 2014·Seizure : the Journal of the British Epilepsy Association·Shamim SahranavardMahmoud Mosaddegh
Jul 12, 2014·Advances in Experimental Medicine and Biology·Ray DingledineF Edward Dudek
Jul 12, 2014·Advances in Experimental Medicine and Biology·Karen S Wilcox, Annamaria Vezzani
Dec 17, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Min-Tae JeonSang Ryong Kim
Jan 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Nur Shafika Mohd SairaziSiti Amrah Sulaiman
Jan 15, 2017·Journal of Neuroinflammation·Kyria M WebsterBridgette D Semple

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Citations

May 22, 2019·Advances in Nutrition·Jae Young KwonSang Ryong Kim
Jan 9, 2020·Journal of Medicinal Food·Jungwan HongSang Ryong Kim
May 19, 2020·Advances in Nutrition·Un Ju Jung, Sang Ryong Kim

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