Abstract
We aimed to determine the protective effects against cerebral ischemia and osteoporosis of Morinda citrifolia extract in experimental menopause. The neuroprotective effect was assessed by giving M. citrifolia leaf extract at doses of 2, 10, and 50 mg/kg BW to the bilateral ovariectomized (OVX) rats for 7 days. Then, they were occluded in the right middle cerebral artery (MCAO) for 90 minutes. The neurological score, brain infarction volume, oxidative stress status, and ERK1/2 and eNOS activities were assessed 24 hours later. M. citrifolia improved neurological score, brain infarction, and brain oxidative stress status in the cortex of OVX rats plus the MCAO. No changes in ERK 1/2 signal pathway and NOS expression were observed in this area. Our data suggested that the neuroprotective effect of the extract might occur partly via the improvement of oxidative stress status in the cortex. The antiosteoporotic effect in OVX rats was also assessed after an 84-day intervention of M. citrifolia. The serum levels of calcium, osteocalcin, and alkaline phosphatase and osteoblast density in the tibia were increased, but the density of osteoclast was decreased in OVX rats which received the extract. Therefore, the current data suggested tha...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Feb 1, 1992·Calcified Tissue International·P CollinN Forest
Feb 15, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Góth
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Apr 1, 1995·Stroke; a Journal of Cerebral Circulation·J H GarciaX J Hu
Jun 23, 1995·The Journal of Biological Chemistry·M H Cobb, E J Goldsmith
Oct 31, 2000·The Journal of Endocrinology·M NasuK Chihara
Jul 17, 2001·Molecular Pharmacology·K TikooT J Monks
Apr 30, 2005·The EMBO Journal·Manel G MedinaPilar Navarro
Jul 27, 2005·Free Radical Biology & Medicine·Isabelle MargaillDominique Lerouet
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Honglian Shi, Ke Jian Liu
Jan 15, 2008·Journal of Neuroscience Research·Nik SaweHeng Zhao
May 20, 2008·Fundamental & Clinical Pharmacology·M Nazam AnsariC D Tripathi
Feb 16, 2010·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hideo Orimo
Aug 24, 2010·Lipids in Health and Disease·Saf-ur Rehman MandukhailAnwarul-Hassan Gilani
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
Nov 2, 2011·Molecular and Cellular Endocrinology·Markus C KühnSven Schinner
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Dec 27, 2012·The World Allergy Organization Journal·Esra BirbenOmer Kalayci
Mar 29, 2014·Journal of Mid-life Health·Sejal B Doshi, Ashok Agarwal
Mar 25, 2013·Neural Regeneration Research·Jianrui LvJunbin Tian
Dec 6, 2014·Oxidative Medicine and Cellular Longevity·Sudarat SungkamaneeWipawee Thukham-mee
Aug 8, 2015·BioMed Research International·Rinaldo Florencio-SilvaPaulo Sérgio Cerri
Jun 1, 2014·Przegla̜d menopauzalny = Menopause review·Marta Teresa Makara-StudzińśkaGrzegorz Jakiel
Sep 25, 2017·MOJ Toxicology·Shashank ShekharFan Fan
Nov 21, 2017·Medical Gas Research·Zhou-Qing ChenGang Chen