Moringa oleifera extract enhances sexual performance in stressed rats

Journal of Zhejiang University. Science. B
Thawatchai PrabsattrooSupaporn Muchimapura

Abstract

Aphrodisiacs are required to improve male sexual function under stressful conditions. Due to the effects of oxidative stress and dopamine on male sexual function, we hypothesized that Moringa oleifera leaves might improve male sexual dysfunction induced by stress. Therefore, the effects on various factors playing important roles in male sexual behavior, such as antioxidant effects, the suppression of monoamine and phosphodiesterase type 5 (PDE-5) activities, serum testosterone and corticosterone levels, and histomorphological changes in the testes, of a hydroethanolic extract of M. oleifera leaves were investigated. Various doses of extract including 10, 50, and 250 mg/kg body weight (BW) were given orally to male Wistar rats before exposure to 12 h-immobilization stress for 7 d. The results demonstrated that the extract showed both antioxidant and monoamine oxidase type B (MAO-B) suppression activities. At 7 d of treatment, the low dose of extract improved sexual performance in stress-exposed rats by decreasing intromission latency and increasing intromission frequency. It also suppressed PDE-5 activity, decreased serum corticosterone level, but increased serum testosterone, numbers of interstitial cells of Leydig and spermato...Continue Reading

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Citations

Jan 8, 2016·Journal of Zhejiang University. Science. B·Supatcharee ArunSitthichai Iamsaard
Feb 15, 2017·Animal : an International Journal of Animal Bioscience·N I El-DesokyZ R Abo-Elezz
Dec 7, 2018·Journal of Zhejiang University. Science. B·Supatcharee ArunSitthichai Iamsaard
Jul 9, 2020·Arquivos brasileiros de cardiologia·Marcia Kiyomi KoikeDenise Yamada Gomes Pinto
Dec 1, 2018·BioMed Research International·Jintanaporn WattanathornSupaporn Muchimapura
Oct 2, 2019·Animals : an Open Access Journal From MDPI·Sheeraz MustafaFangxiong Shi
Jun 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Mohamed Mohamed SolimanWafaa Abdou Mohamed
Nov 3, 2020·Journal of Ethnopharmacology·A Anand GanapathyAlaganandam Kumaran
Apr 22, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Aisha GamboTesleem K Babalola
Aug 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nelisiwe Prenate MasukuSogolo Lucky Lebelo
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei ChenGuang-Jiang Shi
Dec 6, 2020·Sexual Medicine Reviews·Valerie Jia-En SinHwee-Ling Koh
Nov 30, 2021·Journal of Agricultural and Food Chemistry·Saurav GhimireBhakta Prasad Gaire

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